Literature DB >> 773726

The kinetics of beta-granule formation: a morphometric study.

P M Dean.   

Abstract

The rate of formation of beta-granules in mouse islet cells has been studied by morphometry using experimental conditions in which insulin secretion is known to be blocked. The number of beta-granules in a cell is increased by 120%, 45 minutes after a continued glucose stimulus of 16.7 mM. The implications of the results are discussed with respect to the construction of kinetic models for the secretion of insulin by exocytosis.

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Year:  1976        PMID： 773726     DOI： 10.1007/bf00428974

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  18 in total

1.  EFFECTS OF CARBOHYDRATES ON SECRETION OF INSULIN FROM ISOLATED RAT PANCREAS.

Authors:  G M GRODSKY; A A BATTS; L L BENNETT; C VCELLA; N B MCWILLIAMS; D F SMITH
Journal:  Am J Physiol       Date:  1963-10

2.  Ultrastructural morphometry of the pancreatic -cell.

Authors:  P M Dean
Journal:  Diabetologia       Date:  1973-04       Impact factor: 10.122

3.  The molecular organization of the beta granule of the islets of Langerhans.

Authors:  S L Howell
Journal:  Adv Cytopharmacol       Date:  1974

4.  Insulin release by isolated pancreatic islets of the mouse incubated in vitro.

Authors:  E Coll-Garcia; J R Gill
Journal:  Diabetologia       Date:  1969-04       Impact factor: 10.122

Review 5.  The membrane of the chromaffin granule.

Authors:  H Winkler
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1971-06-17       Impact factor: 6.237

6.  Evidence for a precursor in the biosynthesis of insulin.

Authors:  D F Steiner
Journal:  Trans N Y Acad Sci       Date:  1967-11

7.  The effect of glucose on insulin biosynthesis by isolated islets of Langerhans of the rat.

Authors:  G E Morris; A Korner
Journal:  Biochim Biophys Acta       Date:  1970-06

8.  Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro.

Authors:  H G Coore; P J Randle
Journal:  Biochem J       Date:  1964-10       Impact factor: 3.857

9.  Beta granule formation in isolated islets of langerhans: a study by electron microscopic radioautography.

Authors:  S L Howell; M Kostianovsky; P E Lacy
Journal:  J Cell Biol       Date:  1969-09       Impact factor: 10.539

10.  Practical stereological methods for morphometric cytology.

Authors:  E R Weibel; G S Kistler; W F Scherle
Journal:  J Cell Biol       Date:  1966-07       Impact factor: 10.539
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  2 in total

Review 1.  Kinetic aspects of compartmental storage and secretion of insulin and zinc.

Authors:  G Gold; G M Grodsky
Journal:  Experientia       Date:  1984-10-15

2.  Effects of prolonged maternal fast on the pancreas of 18-21-day-old foetal rats. Ultrastructural and morphometric study of the beta cells.

Authors:  H Perrier-Barta
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249
  2 in total

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