Literature DB >> 7737230

Improvement of the diuretic effect of triamterene via solid dispersion technique with PEG 4000.

M J Arias1, J M Gines, J R Moyano, M J Perez-Barrales, M T Vela, A M Rabasco.   

Abstract

The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its absorption rate, via solid dispersion using PEG 4000. The approach of solid dispersions was found useful for optimizing the pharmacokinetic of triamterene in rats.

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Year:  1994        PMID: 7737230     DOI: 10.1007/BF03188855

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN: 0378-7966            Impact factor:   2.441


  6 in total

1.  PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE.

Authors:  L W DITTERT; T HIGUCHI; D R REESE
Journal:  J Pharm Sci       Date:  1964-11       Impact factor: 3.534

Review 2.  Pharmaceutical applications of solid dispersion systems.

Authors:  W L Chiou; S Riegelman
Journal:  J Pharm Sci       Date:  1971-09       Impact factor: 3.534

3.  Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin.

Authors:  W L Chiou; S Riegelman
Journal:  J Pharm Sci       Date:  1969-12       Impact factor: 3.534

4.  Rapid method for the determination of the diuretic triamterene and its metabolites in plasma and urine by high-performance liquid chromatography.

Authors:  K J Swart; H Botha
Journal:  J Chromatogr       Date:  1987-01-23

5.  Dissolution, stability, and absorption characteristics of dicumarol in polyethylene glycol 4000 solid dispersions.

Authors:  W R Ravis; C Y Chen
Journal:  J Pharm Sci       Date:  1981-12       Impact factor: 3.534

6.  Physicochemical and structural studies of triamterene.

Authors:  O Dahl; K H Ziedrich; G J Marek; H H Paradies
Journal:  J Pharm Sci       Date:  1989-07       Impact factor: 3.534

  6 in total

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