Literature DB >> 7736527

Functional expression in mast cells of chimeric receptors with antibody specificity.

N L Bach1, T Waks, D G Schindler, Z Eshhar.   

Abstract

Chimeric genes composed of a single-chain Fv domain (scFv) of an antibody linked with receptor chains normally present in cells of hematopoietic origin were constructed. Such genes could be expressed as functional surface receptors in the RBL-2H3 (rat basophilic leukemia) mast cell line. The chimeric receptors exhibited binding properties of an antibody molecule and triggered degranulation of transfected mast cells on stimulation with antigen. Genetically engineered designer cells (e.g., T-lymphocytes, mast cells, or natural killer cells), equipped with built-in antibody-type recognition, can be now exploited for immunotherapy.

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Year:  1994        PMID： 7736527     DOI： 10.1007/bf02789233

Source DB:  PubMed          Journal:  Cell Biophys        ISSN： 0163-4992


  12 in total

Review 1.  Murine Fc gamma RII and III in mast cell activation.

Authors:  M Daëron; S Latour; C Hückel; C Bonnerot; W H Fridman
Journal:  Immunobiology       Date:  1992-08       Impact factor: 3.144

2.  Reactivity of cloned, expressed human Fc gamma RIII isoforms with monoclonal antibodies which distinguish cell-type-specific and allelic forms of Fc gamma RIII.

Authors:  M L Trounstine; G A Peltz; H Yssel; T W Huizinga; A E von dem Borne; H Spits; K W Moore
Journal:  Int Immunol       Date:  1990       Impact factor: 4.823

3.  Single-chain antigen-binding proteins.

Authors:  R E Bird; K D Hardman; J W Jacobson; S Johnson; B M Kaufman; S M Lee; T Lee; S H Pope; G S Riordan; M Whitlow
Journal:  Science       Date:  1988-10-21       Impact factor: 47.728

Review 4.  Receptors for IgE on mast cells and basophils.

Authors:  A Froese
Journal:  Prog Allergy       Date:  1984

5.  Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity.

Authors:  Z Eshhar; M Ofarim; T Waks
Journal:  J Immunol       Date:  1980-02       Impact factor: 5.422

Review 6.  Endowing T cells with antibody specificity using chimeric T cell receptors.

Authors:  G Gross; Z Eshhar
Journal:  FASEB J       Date:  1992-12       Impact factor: 5.191

7.  Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

Authors:  L L Lanier; G Yu; J H Phillips
Journal:  J Immunol       Date:  1991-03-01       Impact factor: 5.422

8.  Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Authors:  Z Eshhar; T Waks; G Gross; D G Schindler
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

9.  Role of associated gamma-chain in tyrosine kinase activation via murine Fc gamma RIII.

Authors:  C Bonnerot; S Amigorena; D Choquet; R Pavlovich; V Choukroun; W H Fridman
Journal:  EMBO J       Date:  1992-07       Impact factor: 11.598

10.  Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell antigen receptor.

Authors:  T Rutledge; P Cosson; N Manolios; J S Bonifacino; R D Klausner
Journal:  EMBO J       Date:  1992-09       Impact factor: 11.598
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  1 in total

Review 1.  The T-body approach: potential for cancer immunotherapy.

Authors:  Z Eshhar; N Bach; C J Fitzer-Attas; G Gross; J Lustgarten; T Waks; D G Schindler
Journal:  Springer Semin Immunopathol       Date:  1996
  1 in total

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