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Literature DB >> 7735828

Recombining the structures of HIV integrase, RuvC and RNase H.

Abstract

The recently reported crystal structures of two recombination enzymes, the catalytic domain of HIV integrase and Escherichia coli RuvC, an endonuclease, are surprisingly similar to that of ribonuclease H suggesting the possibility that they have a common enzymatic mechanism.

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Year: 1995 PMID： 7735828 DOI： 10.1016/s0969-2126(01)00142-3

Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006

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Cited

83 in total

1. Catalytic center of an archaeal type 2 ribonuclease H as revealed by X-ray crystallographic and mutational analyses.

Authors: A Muroya; D Tsuchiya; M Ishikawa; M Haruki; M Morikawa; S Kanaya; K Morikawa
Journal: Protein Sci Date: 2001-04 Impact factor: 6.725

2. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.

Authors: D R Kim; Y Dai; C L Mundy; W Yang; M A Oettinger
Journal: Genes Dev Date: 1999-12-01 Impact factor: 11.361

3. Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus.

Authors: C S Bond; M Kvaratskhelia; D Richard; M F White; W N Hunter
Journal: Proc Natl Acad Sci U S A Date: 2001-05-01 Impact factor: 11.205

4. Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.

Authors: Marta Nadal; Philippe J Mas; Phillipe J Mas; Alexandre G Blanco; Carme Arnan; Maria Solà; Darren J Hart; Miquel Coll
Journal: Proc Natl Acad Sci U S A Date: 2010-08-30 Impact factor: 11.205

5. Understanding the effect of magnesium ion concentration on the catalytic activity of ribonuclease H through computation: does a third metal binding site modulate endonuclease catalysis?

Authors: Ming-Hsun Ho; Marco De Vivo; Matteo Dal Peraro; Michael L Klein
Journal: J Am Chem Soc Date: 2010-10-06 Impact factor: 15.419

Recombining the structures of HIV integrase, RuvC and RNase H.

1. Catalytic center of an archaeal type 2 ribonuclease H as revealed by X-ray crystallographic and mutational analyses.

2. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.

3. Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus.

4. Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.

5. Understanding the effect of magnesium ion concentration on the catalytic activity of ribonuclease H through computation: does a third metal binding site modulate endonuclease catalysis?

6. Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.

7. Comparative sequence analysis of IS50/Tn5 transposase.

8. Cation trafficking propels RNA hydrolysis.

9. Hepatitis B virus genetic diversity has minimal impact on sensitivity of the viral ribonuclease H to inhibitors.

10. Phosphodiester cleavage in ribonuclease H occurs via an associative two-metal-aided catalytic mechanism.