Literature DB >> 7735686

On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry.

H J Leis1, D Zach, E Huber, L Ziermann, H Gleispach, W Windischhofer.   

Abstract

1. The proposed blocker of receptor-operated calcium channels, SK&F 96365 was shown to inhibit formation of prostaglandin E2 in two osteoblast-like cell lines, MC3T3-E1 and UMR-106 in a dose-dependent manner at an IC50 of 3-4 microM. Inhibition was observed with various stimuli (arachidonic acid, bradykinin and calcium ionophore A23187). 2. This effect was also observed in human platelets, where SK&F 96365 dose-dependently blocked thromboxane biosynthesis and formation of 12-hydroxy-heptadecatrienoic acid after stimulation with arachidonic acid (IC50 = 4 microM). 3. The compound had no effect on 12-hydroxy-eicosatetraenoic acid production by human platelets. Additionally, linoleic acid oxidation by soybean 15-lipoxidase was not impaired by SK&F 96365. The results thus provide evidence for cyclo-oxygenase inhibition by SK&F 96365 at concentrations used to block receptor-operated calcium influx.

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Year:  1995        PMID： 7735686      PMCID： PMC1510006          DOI： 10.1111/j.1476-5381.1995.tb17181.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  25 in total

1.  Calcium channels in thrombin-activated human platelet membrane.

Authors:  A Zschauer; C van Breemen; F R Bühler; M T Nelson
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

Review 2.  The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel.

Authors:  K P Campbell; A T Leung; A H Sharp
Journal:  Trends Neurosci       Date:  1988-10       Impact factor: 13.837

Review 3.  Pathways of Ca2+ influx at the plasma membrane: voltage-, receptor-, and second messenger-operated channels.

Authors:  J Meldolesi; T Pozzan
Journal:  Exp Cell Res       Date:  1987-08       Impact factor: 3.905

4.  Measurement of prostaglandins, thromboxanes and hydroxy fatty acids by stable isotope dilution gas chromatography/mass spectrometry.

Authors:  H J Leis; E Hohenester; H Gleispach; E Malle; B Mayer
Journal:  Biomed Environ Mass Spectrom       Date:  1987-11

5.  Inhibition of rat liver microsomal cytochrome P-450 steroid hydroxylase reactions by imidazole antimycotic agents.

Authors:  J J Sheets; J I Mason; C A Wise; R W Estabrook
Journal:  Biochem Pharmacol       Date:  1986-02-01       Impact factor: 5.858

6.  Cyclooxygenase and lipoxygenase metabolites during platelet aggregation: quantitative measurement by negative ion chemical ionization--gas chromatography/mass spectrometry.

Authors:  E Malle; J Nimpf; H J Leis; H Wurm; H Gleispach; G M Kostner
Journal:  Prostaglandins Leukot Med       Date:  1987-04

7.  Extracellular Ca2+ sensing by the osteoblast-like cell line, MC3T3-E1.

Authors:  H J Leis; D Zach; E Huber; L Ziermann; H Gleispach; W Windischhofer
Journal:  Cell Calcium       Date:  1994-06       Impact factor: 6.817

8.  Quantitative measurement of 5-, 12-, and 15-hydroxyeicosatetraenoic acid together with 12-hydroxyheptadecatrienoic acid by stable isotope dilution gas chromatography-negative ion chemical ionization-mass spectrometry.

Authors:  H J Leis; E Malle; B Mayer; G M Kostner; H Esterbauer; H Gleispach
Journal:  Anal Biochem       Date:  1987-05-01       Impact factor: 3.365

9.  Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor.

Authors:  R D Nolan; R M Danilowicz; T E Eling
Journal:  Mol Pharmacol       Date:  1988-06       Impact factor: 4.436

10.  Preparation of 18O-labelled standards of hydroxy-eicosatetraenoic acids and thromboxanes for quantitative measurement by gas chromatography/mass spectrometry.

Authors:  H J Leis; E Malle; R Moser; J Nimpf; G M Kostner; H Esterbauer; H Gleispach
Journal:  Biomed Environ Mass Spectrom       Date:  1986-09
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  6 in total

1.  Capacitative calcium entry and proliferation of human osteoblast-like MG-63 cells.

Authors:  D Labelle; C Jumarie; R Moreau
Journal:  Cell Prolif       Date:  2007-12       Impact factor: 6.831

2.  SK & F 96365 inhibits carbachol-induced phosphoinositide turnover in human neuroblastoma SH-SY5Y and rat cerebellar granule cells.

Authors:  W W Lin; C W Wang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-06       Impact factor: 3.000

3.  Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation.

Authors:  H C Köfeler; G Fauler; W Windischhofer; H J Leis
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

4.  Listeria monocytogenes phospholipase C-dependent calcium signaling modulates bacterial entry into J774 macrophage-like cells.

Authors:  S J Wadsworth; H Goldfine
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

5.  Inhibition of prostanoid formation in intact cells by 2,5-di-(tert-butyl)-1,4-benzohydroquinone, a blocker of Ca(2+)-ATPases.

Authors:  H J Leis; D Zach; E Huber; L Ziermann; H Gleispach; W Windischhofer
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

6.  Transduction mechanism(s) of Na-saccharin in the blowfly Protophormia terraenovae: evidence for potassium and calcium conductance involvement.

Authors:  Carla Masala; Paolo Solari; Giorgia Sollai; Roberto Crnjar; Anna Liscia
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2009-11-08       Impact factor: 1.836
  6 in total

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