Literature DB >> 7734923

Therapeutic potential of meso 2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane 1-sulfonate in chronic arsenic intoxication in rats.

S J Flora1, S N Dube, U Arora, G M Kannan, M K Shukla, P R Malhotra.   

Abstract

The therapeutic efficacy of two thiol chelators, meso 2,3-dimercaptosuccinic acid (DMSA) or 2,3-dimercaptopropane sulfonate (DMPS) in treating chronic arsenic intoxication was investigated in male rats. Both the chelators were effective in promoting urinary arsenic excretion and restoring arsenic induced inhibition of blood delta-aminolevulinic acid dehydratase activity and hepatic glutathione level. Elevation of urinary delta-aminolevulinic acid excretion and arsenic concentration in blood, liver and kidneys were reduced significantly by both the chelators. Histopathological lesions induced by arsenic were also effectively reduced by the above chelators. DMSA being more effective than DMPS. The results suggest DMSA and DMPS to be effective antidotes for treating chronic arsenic toxicity in experimental animals.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7734923     DOI： 10.1007/bf00142009

Source DB:  PubMed          Journal:  Biometals        ISSN： 0966-0844            Impact factor:   2.949


  22 in total

1.  [Conversion of unithiol in the organism].

Authors:  N I LUGANSKII; Iu I LOBODA
Journal:  Farmakol Toksikol       Date:  1960 Jul-Aug

Review 2.  Role of 2,3-dimercaptosuccinic acid in the treatment of heavy metal poisoning.

Authors:  J H Graziano
Journal:  Med Toxicol       Date:  1986 May-Jun

3.  European standardized method for the determination of delta-aminolevulinic acid dehydratase activity in blood.

Authors:  A Berlin; K H Schaller
Journal:  Z Klin Chem Klin Biochem       Date:  1974-08

4.  Effect of some arsenic antagonists on the toxicity, distribution and excretion of arsenite and arsenate in rats.

Authors:  A M Hilmy; N A el-Domiaty; M A Kamal; M A Mohamed; W E Abou Samra
Journal:  Comp Biochem Physiol C       Date:  1991

5.  Protection of mice against lethal effects of sodium arsenite--a quantitative comparison of a number of chelating agents.

Authors:  H V Aposhian; C H Tadlock; T E Moon
Journal:  Toxicol Appl Pharmacol       Date:  1981-12       Impact factor: 4.219

6.  The effect of chelating agents on the excretion of endogenous metals.

Authors:  L R Cantilena; C D Klaassen
Journal:  Toxicol Appl Pharmacol       Date:  1982-05       Impact factor: 4.219

Review 7.  DMSA and DMPS--water soluble antidotes for heavy metal poisoning.

Authors:  H V Aposhian
Journal:  Annu Rev Pharmacol Toxicol       Date:  1983       Impact factor: 13.820

8.  Biotransformation of trivalent and pentavalent inorganic arsenic in mice and rats.

Authors:  M Vahter
Journal:  Environ Res       Date:  1981-08       Impact factor: 6.498

9.  Effect of subacute low level dietary sodium arsenite on dogs.

Authors:  R D Neiger; G D Osweiler
Journal:  Fundam Appl Toxicol       Date:  1989-10

10.  CLINICAL USES OF 2,3-DIMERCAPTOPROPANOL (BAL). III. STUDIES ON THE TOXICITY OF BAL ON PERCUTANEOUS AND PARENTERAL ADMINISTRATION.

Authors:  M B Sulzberger; R L Baer; A Kanof
Journal:  J Clin Invest       Date:  1946-07       Impact factor: 14.808
View more
  5 in total

1.  Prophylactic role of Enhydra fluctuans against arsenic-induced hepatotoxicity via anti-apoptotic and antioxidant mechanisms.

Authors:  Tarun K Dua; Saikat Dewanjee; Ritu Khanra
Journal:  Redox Rep       Date:  2016-03-10       Impact factor: 4.412

2.  Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice.

Authors:  Victoria K Mwaeni; James N Nyariki; Ngalla Jillani; George Omwenga; Mathew Ngugi; Alfred Orina Isaac
Journal:  BMC Pharmacol Toxicol       Date:  2021-04-07       Impact factor: 2.483

3.  Combined administration of taurine and monoisoamyl DMSA protects arsenic induced oxidative injury in rats.

Authors:  Swaran J S Flora; Swapnila Chouhan; Gurusamy M Kannan; Megha Mittal; Harimohan Swarnkar
Journal:  Oxid Med Cell Longev       Date:  2008 Oct-Dec       Impact factor: 6.543

4.  Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action.

Authors:  Kuladip Jana; Subarna Jana; Prabhat Kumar Samanta
Journal:  Reprod Biol Endocrinol       Date:  2006-02-16       Impact factor: 5.211

5.  Protective effect of silymarin on viability, motility and mitochondrial membrane potential of ram sperm treated with sodium arsenite.

Authors:  Farzaneh Eskandari; Hamid Reza Momeni
Journal:  Int J Reprod Biomed (Yazd)       Date:  2016-06
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.