| Literature DB >> 7734641 |
M van der Elst1, A R Dijkema, C P Klein, P Patka, H J Haarman.
Abstract
In order to develop a biodegradable interlocking nail for fracture fixation, polylactic acid (PLLA) rods were implanted in the femoral bone of young pigs. A midshaft osteotomy was performed in order to mimic a fracture. The tissue response to PLLA rods versus stainless steel rods was studied after 1 and 3 months of implantation. Fracture-healing characteristics and chemical and mechanical properties of the PLLA rods were studied after explantation. Mechanical properties deteriorated during implantation and chemical properties changed significantly in 1 and 3 months of implantation. PLLA and stainless steel induced a similar tissue reaction during the studied implantation time of 3 months.Entities:
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Year: 1995 PMID： 7734641 DOI： 10.1016/0142-9612(95)98270-o
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479