Literature DB >> 7734082

THC-induced place and taste aversions in Lewis and Sprague-Dawley rats.

L A Parker1, T Gillies.   

Abstract

The hedonic properties of delta-9-tetrahydrocannabinol (THC) were assessed in place and taste conditioning paradigms in both Lewis and Sprague-Dawley rat strains. THC produced place avoidance, taste avoidance, and aversive taste reactivity responses in both strains. The Lewis strain displayed more aversive taste reactions and a stronger taste avoidance when conditioned with lower doses of THC than did the Sprague-Dawley strain of rats. THC is an anomalous drug of abuse that appears to be aversive to rats when assessed by these measures.

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Year:  1995        PMID： 7734082     DOI： 10.1037//0735-7044.109.1.71

Source DB:  PubMed          Journal:  Behav Neurosci        ISSN： 0735-7044            Impact factor:   1.912


  42 in total

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