Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A.

Literature DB >> 7733864

Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A.

Abstract

Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse-transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.

Entities: Gene Species

Mesh：

Substances：

Year: 1995 PMID： 7733864 PMCID： PMC1136651 DOI： 10.1042/bj3070327

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

26 in total

1. DETERMINATION OF THE CODING RATIO BASED ON MOLECULAR WEIGHT OF MESSENGER RIBONUCLEIC ACID ASSOCIATED WITH ERGOSOMES OF DIFFERENT AGGREGATE SIZE.

Authors: T STAEHELIN; F O WETTSTEIN; H OURA; H NOLL
Journal: Nature Date: 1964-01-18 Impact factor: 49.962

2. Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A.

Authors: T Voss; K Melchers; G Scheirle; K P Schäfer
Journal: Am J Respir Cell Mol Biol Date: 1991-01 Impact factor: 6.914

3. Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein.

Authors: J Floros; R Steinbrink; K Jacobs; D Phelps; R Kriz; M Recny; L Sultzman; S Jones; H W Taeusch; H A Frank
Journal: J Biol Chem Date: 1986-07-05 Impact factor: 5.157

4. Aspects of secondary and quaternary structure of surfactant protein A from canine lung.

Authors: R J King; D Simon; P M Horowitz
Journal: Biochim Biophys Acta Date: 1989-02-20

5. Postnatal stimulation of rat surfactant protein A synthesis by dexamethasone.

Authors: J Floros; D S Phelps; H P Harding; S Church; J Ware
Journal: Am J Physiol Date: 1989-08

6. Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.

Authors: H L Foyt; D LeRoith; C T Roberts
Journal: J Biol Chem Date: 1991-04-15 Impact factor: 5.157

7. Deficient lung surfactant apoproteins in amniotic fluid with mature phospholipid profile from diabetic pregnancies.

Authors: S L Katyal; J S Amenta; G Singh; J A Silverman
Journal: Am J Obstet Gynecol Date: 1984-01-01 Impact factor: 8.661

8. Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells.

Authors: L G Dobbs; J R Wright; S Hawgood; R Gonzalez; K Venstrom; J Nellenbogen
Journal: Proc Natl Acad Sci U S A Date: 1987-02 Impact factor: 11.205

9. Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C.

Authors: M C Williams; S Hawgood; R L Hamilton
Journal: Am J Respir Cell Mol Biol Date: 1991-07 Impact factor: 6.914

10. Reconstitution of tubular myelin from synthetic lipids and proteins associated with pig pulmonary surfactant.

Authors: Y Suzuki; Y Fujita; K Kogishi
Journal: Am Rev Respir Dis Date: 1989-07

12 in total

1. 14-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA.

Authors: Georgios T Noutsios; Paul Ghattas; Stephanie Bennett; Joanna Floros
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2015-05-22 Impact factor: 5.464

Review 2. Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins.

Authors: Frederico Vieira; Johannes W Kung; Faizah Bhatti
Journal: Ann Anat Date: 2017-03-27 Impact factor: 2.698

10. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure.

Authors: Georgios T Noutsios; Patricia Silveyra; Faizah Bhatti; Joanna Floros
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2013-03-22 Impact factor: 5.464

Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A.

1. DETERMINATION OF THE CODING RATIO BASED ON MOLECULAR WEIGHT OF MESSENGER RIBONUCLEIC ACID ASSOCIATED WITH ERGOSOMES OF DIFFERENT AGGREGATE SIZE.

2. Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A.

3. Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein.

4. Aspects of secondary and quaternary structure of surfactant protein A from canine lung.

5. Postnatal stimulation of rat surfactant protein A synthesis by dexamethasone.

6. Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.

7. Deficient lung surfactant apoproteins in amniotic fluid with mature phospholipid profile from diabetic pregnancies.

8. Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells.

9. Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C.

10. Reconstitution of tubular myelin from synthetic lipids and proteins associated with pig pulmonary surfactant.

1. 14-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA.

Review 2. Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins.

Review 3. Surfactant protein-A: new insights into an old protein--II.

4. An alternatively spliced surfactant protein B mRNA in normal human lung: disease implication.

5. The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation.

6. Effect of genotype on the levels of surfactant protein A mRNA and on the SP-A2 splice variants in adult humans.

7. Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants.

Review 8. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.

9. Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution.

10. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure.