Literature DB >> 7730220

Amoxycillin causes an enhanced uptake of metronidazole in Actinobacillus actinomycetemcomitans: a mechanism of synergy.

M J Pavicić1, A J van Winkelhoff, Y A Pavicić-Temming, J de Graaff.   

Abstract

We investigated the influence of sub-inhibitory concentrations amoxycillin on metronidazole uptake of the metronidazole-susceptible facultative microorganism Actinobacillus actinomycetemcomitans. The rate of metronidazole uptake by bacterial cells simultaneously incubated with amoxycillin was higher than uptake in cells incubated with metronidazole alone. This phenomenon may explain the recently reported in-vitro synergic interaction between metronidazole and amoxycillin against A. actinomycetemcomitans.

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Year:  1994        PMID： 7730220     DOI： 10.1093/jac/34.6.1047

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  5 in total

Review 1.  Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs.

Authors:  Sabrina L Buset; Nicola U Zitzmann; Roland Weiger; Clemens Walter
Journal:  Clin Oral Investig       Date:  2015-06-12       Impact factor: 3.573

2.  Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model.

Authors:  Geisla M S Soares; Flavia Teles; Jacqueline R Starr; Magda Feres; Michele Patel; Lynn Martin; Ricardo Teles
Journal:  Antimicrob Agents Chemother       Date:  2015-03-02       Impact factor: 5.191

3.  Intracanal Antibiotic Medication for Sustained Root Surface Disinfection-A Laboratory Evaluation.

Authors:  Markus Tobias Winfried Zaruba; Tilla Filli; Dan-Krister Rechenberg; Thomas Thurnheer; Thomas Attin; Patrick Roger Schmidlin
Journal:  Open Dent J       Date:  2015-12-11

4.  Comparative Evaluation of Cost-Effectiveness, Clinical and Microbiological Parameters of Systemic Antibiotics Versus Local Drug Delivery in Aggressive Periodontitis.

Authors:  Brij Nandan; Debarchan Barman Roy; Vandana A Pant; Vandana Gupta; Upendra Bhaduria; Harpreet Kaur; Ojas Gupta
Journal:  Cureus       Date:  2022-01-06

5.  Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm.

Authors:  Orit Oettinger-Barak; Stuart G Dashper; Deanne V Catmull; Geoffrey G Adams; Michael N Sela; Eli E Machtei; Eric C Reynolds
Journal:  J Oral Microbiol       Date:  2013-05-08       Impact factor: 5.474
  5 in total

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