Literature DB >> 7729552

The thrombin receptor in human platelets is coupled to a GTP binding protein of the G alpha q family.

M L Benka1, M Lee, G R Wang, S Buckman, A Burlacu, L Cole, A DePina, P Dias, A Granger, B Grant.   

Abstract

The thrombin receptor is a G protein-coupled receptor, but the G proteins functionally coupled to this receptor in human platelets are not yet definitively identified. Thrombin stimulation of platelets leads to phospholipase C-mediated increases in intracellular calcium, and previous studies have suggested that the thrombin receptor is coupled to members of the Gq family. We now demonstrate direct GTPase activation by thrombin receptor activation peptide (TRAP) in human platelet membranes, and specific inhibition of TRAP-activated GTPase by antibodies to Gq. These data demonstrate functional coupling of the thrombin receptor to a member of the Gq family.

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Year:  1995        PMID： 7729552     DOI： 10.1016/0014-5793(95)00278-h

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

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Review 2.  Protease-activated receptors: regulation of neuronal function.

Authors:  Toshiyuki Saito; Nigel W Bunnett
Journal:  Neuromolecular Med       Date:  2005       Impact factor: 3.843

Review 3.  Proteases display biased agonism at protease-activated receptors: location matters!

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4.  Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.

Authors:  Buxin Chen; David P Siderovski; Richard R Neubig; Mark A Lawson; Joann Trejo
Journal:  J Biol Chem       Date:  2013-12-02       Impact factor: 5.157

5.  A molecular mechanism for signaling between seven-transmembrane receptors: evidence for a redistribution of G proteins.

Authors:  Y Djellas; K Antonakis; G C Le Breton
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

6.  Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses.

Authors:  J Gabbeta; X Yang; M A Kowalska; L Sun; N Dhanasekaran; A K Rao
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

Review 7.  Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.

Authors:  T A Fields; P J Casey
Journal:  Biochem J       Date:  1997-02-01       Impact factor: 3.857

8.  Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase.

Authors:  G R Wang; Y Zhu; P V Halushka; T M Lincoln; M E Mendelsohn
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

9.  N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization.

Authors:  Antonio G Soto; JoAnn Trejo
Journal:  J Biol Chem       Date:  2010-04-05       Impact factor: 5.157

10.  Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides.

Authors:  F Nakamura; L Huang; K Pestonjamasp; E J Luna; H Furthmayr
Journal:  Mol Biol Cell       Date:  1999-08       Impact factor: 4.138
  10 in total

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