Literature DB >> 7729550

High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: isolation and characterization of its cDNA clone.

N Yamazaki1, Y Shinohara, A Shima, H Terada.   

Abstract

To characterize energy metabolism in rat brown adipose tissue (BAT), we carried out differential screening of a cDNA library of BAT with a cDNA probe of white adipose tissue (WAT) and isolated one cDNA clone. It contained a single open reading frame of 2,316 bases which encodes a protein of 88.2 kDa. The predicted amino acid sequence showed the highest homology (62.6%) with that of rat carnitine palmitoyltransferase I (CPTI). The transcript corresponding to this cDNA was found to be abundantly expressed in BAT and heart. Therefore, the isolated clone is concluded to encode a CPTI like protein expressed in BAT and heart.

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Year:  1995        PMID： 7729550     DOI： 10.1016/0014-5793(95)00277-g

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme.

Authors:  Nigel T Price; Vicky N Jackson; Feike R van der Leij; Jacqueline M Cameron; Maureen T Travers; Beatrijs Bartelds; Nicolette C Huijkman; Victor A Zammit
Journal:  Biochem J       Date:  2003-06-15       Impact factor: 3.857

2.  Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.

Authors:  M Morillas; J Clotet; B Rubí; D Serra; J Ariño; F G Hegardt; G Asins
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

Review 3.  Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases.

Authors:  Harjot K Saini-Chohan; Ryan W Mitchell; Frédéric M Vaz; Teresa Zelinski; Grant M Hatch
Journal:  J Lipid Res       Date:  2011-11-07       Impact factor: 5.922

4.  Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.

Authors:  Patricia Carrasco; Ignasi Sahún; Jerome McDonald; Sara Ramírez; Jordi Jacas; Esther Gratacós; Adriana Y Sierra; Dolors Serra; Laura Herrero; Amparo Acker-Palmer; Fausto G Hegardt; Mara Dierssen; Núria Casals
Journal:  J Biol Chem       Date:  2012-04-26       Impact factor: 5.157

5.  A Novel Mutation in CPT1A Resulting in Hepatic CPT Deficiency.

Authors:  Monique Fontaine; Anne-Frédérique Dessein; Claire Douillard; Dries Dobbelaere; Michèle Brivet; Audrey Boutron; Mokhtar Zater; Karine Mention-Mulliez; Annie Martin-Ponthieu; Christine Vianey-Saban; Gilbert Briand; Nicole Porchet; Joseph Vamecq
Journal:  JIMD Rep       Date:  2012-01-31

6.  Cloning and characterization of the promoter for the liver isoform of the rat carnitine palmitoyltransferase I (L-CPT I) gene.

Authors:  E A Park; M L Steffen; S Song; V M Park; G A Cook
Journal:  Biochem J       Date:  1998-02-15       Impact factor: 3.857

Review 7.  Mitochondrial fatty acid oxidation in obesity.

Authors:  Dolors Serra; Paula Mera; Maria Ida Malandrino; Joan Francesc Mir; Laura Herrero
Journal:  Antioxid Redox Signal       Date:  2012-10-05       Impact factor: 8.401

8.  Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues.

Authors:  S T Swanson; D W Foster; J D McGarry; N F Brown
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

9.  Homozygous carnitine palmitoyltransferase 1b (muscle isoform) deficiency is lethal in the mouse.

Authors:  Shaonin Ji; Yun You; Janos Kerner; Charles L Hoppel; Trenton R Schoeb; Wallace S H Chick; Doug A Hamm; J Daniel Sharer; Philip A Wood
Journal:  Mol Genet Metab       Date:  2007-11-19       Impact factor: 4.797

10.  Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells.

Authors:  David Sebastián; Maria Guitart; Celia García-Martínez; Caroline Mauvezin; Josep M Orellana-Gavaldà; Dolors Serra; Anna M Gómez-Foix; Fausto G Hegardt; Guillermina Asins
Journal:  J Lipid Res       Date:  2009-05-09       Impact factor: 5.922
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