OBJECTIVE: To assess whether lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic cardiovascular disease in diabetes. RESEARCH DESIGN AND METHODS: We studied 221 patients with non-insulin-dependent diabetes mellitus (NIDDM) without diabetic complications who were followed for 2.2-3.1 years. Their serum Lp(a) levels were semiquantified by a rapid electrophoretic method that accurately discriminates high from low serum Lp(a) at the 20 mg/dl level. RESULTS: Seven of 105 diabetic patients with a high serum Lp(a) experienced a clinical event related to atherosclerotic cardiovascular disease. This incidence was significantly higher than that of the 110 diabetic patients with a low serum Lp(a). The logistic regression analysis revealed that Lp(a) was an independent risk factor for the event. CONCLUSIONS: Lp(a) is a significant risk factor for atherosclerotic cardiovascular disease in NIDDM.
OBJECTIVE: To assess whether lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic cardiovascular disease in diabetes. RESEARCH DESIGN AND METHODS: We studied 221 patients with non-insulin-dependent diabetes mellitus (NIDDM) without diabetic complications who were followed for 2.2-3.1 years. Their serum Lp(a) levels were semiquantified by a rapid electrophoretic method that accurately discriminates high from low serum Lp(a) at the 20 mg/dl level. RESULTS: Seven of 105 diabeticpatients with a high serum Lp(a) experienced a clinical event related to atherosclerotic cardiovascular disease. This incidence was significantly higher than that of the 110 diabeticpatients with a low serum Lp(a). The logistic regression analysis revealed that Lp(a) was an independent risk factor for the event. CONCLUSIONS:Lp(a) is a significant risk factor for atherosclerotic cardiovascular disease in NIDDM.
Authors: J D Zampoulakis; A A Kyriakousi; K A Poralis; N T Karaminas; I D Palermos; E T Chimonas; D V Cokkinos Journal: Clin Cardiol Date: 2000-12 Impact factor: 2.882
Authors: Samia Mora; Pia R Kamstrup; Nader Rifai; Børge G Nordestgaard; Julie E Buring; Paul M Ridker Journal: Clin Chem Date: 2010-05-28 Impact factor: 8.327
Authors: H Sone; S Tanaka; S Iimuro; S Tanaka; K Oida; Y Yamasaki; S Oikawa; S Ishibashi; S Katayama; H Yamashita; H Ito; Y Yoshimura; Y Ohashi; Y Akanuma; N Yamada Journal: Diabetologia Date: 2010-01-07 Impact factor: 10.122