R C Karl1, S K Smith, P J Fabri. 1. Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA.
Abstract
BACKGROUND: As the population ages, more elderly individuals will be at risk for the development of gastrointestinal malignancies traditionally treated with radical operation. In the past, many major cancer operations were reserved for patients < 65 or 70 years of age, but as the life expectancy for a 70-year-old has improved, this policy has been questioned. METHODS: We examined the records of 124 consecutive patients who underwent one of three major operations (esophagogastrectomy, major liver resection, pancreatoduodenectomy) for gastrointestinal cancer during the past 6 years to determine if preoperative risk factors, operative mortality, length of stay, length of procedure, estimated blood loss, rate of major complication, or Kaplan-Meier survival was different for patients > or = 70 years of age as compared with younger patients. RESULTS: For patients at our institution undergoing esophagogastrectomy, major liver resection, or pancreatoduodenectomy, we found no significant difference in any of the parameters measured. There was no significant difference in any parameter when comparing patients > or = 70 versus < 70 years of age. CONCLUSIONS: We conclude that patients > or = 70 years of age are not necessarily less suitable candidates for major cancer operations than are those < 70 years of age if other risk factors are acceptable. Elderly patients should be included in clinical trials.
BACKGROUND: As the population ages, more elderly individuals will be at risk for the development of gastrointestinal malignancies traditionally treated with radical operation. In the past, many major cancer operations were reserved for patients < 65 or 70 years of age, but as the life expectancy for a 70-year-old has improved, this policy has been questioned. METHODS: We examined the records of 124 consecutive patients who underwent one of three major operations (esophagogastrectomy, major liver resection, pancreatoduodenectomy) for gastrointestinal cancer during the past 6 years to determine if preoperative risk factors, operative mortality, length of stay, length of procedure, estimated blood loss, rate of major complication, or Kaplan-Meier survival was different for patients > or = 70 years of age as compared with younger patients. RESULTS: For patients at our institution undergoing esophagogastrectomy, major liver resection, or pancreatoduodenectomy, we found no significant difference in any of the parameters measured. There was no significant difference in any parameter when comparing patients > or = 70 versus < 70 years of age. CONCLUSIONS: We conclude that patients > or = 70 years of age are not necessarily less suitable candidates for major cancer operations than are those < 70 years of age if other risk factors are acceptable. Elderly patients should be included in clinical trials.
Authors: Roberto Ballarin; Mario Spaggiari; Fabrizio Di Benedetto; Roberto Montalti; Michele Masetti; Nicola De Ruvo; Antonio Romano; Gian Piero Guerrini; Maria Grazia De Blasiis; Giorgio Enrico Gerunda Journal: J Gastrointest Surg Date: 2008-09-11 Impact factor: 3.452
Authors: J Figueras; E Ramos; S López-Ben; J Torras; M Albiol; L Llado; H D González; A Rafecas Journal: Clin Transl Oncol Date: 2007-06 Impact factor: 3.340