| Literature DB >> 7728399 |
A S Williams1, Y L Punn, N Amos, A M Cooper, B D Williams.
Abstract
The ability of methotrexate (MTX) and a liposomal preparation containing a lipophilic conjugate of methotrexate (MTX-LIPO) to modulate pro-inflammatory mediator release from lipopolysaccharide-stimulated human peripheral blood monocytes was investigated. At non-toxic concentrations MTX-LIPO (10 micrograms MTX per 250 micrograms lipid) was a potent inhibitor of both IL-1 beta and TNF release resulting in 70.07 +/- 2.3% and 59.19 +/- 2.36% (mean +/- S.E.M.) inhibition, respectively, whereas empty liposomes (E-LIPO; 250 micrograms lipid/well) of the same lipid composition and free MTX (up to 100 micrograms/well) had no effect on either mediator.Entities:
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Year: 1995 PMID： 7728399 DOI： 10.1093/rheumatology/34.3.241
Source DB: PubMed Journal: Br J Rheumatol ISSN： 0263-7103