Literature DB >> 7726856

Failure of copper incorporation into ceruloplasmin in the Golgi apparatus of LEC rat hepatocytes.

Y Murata1, E Yamakawa, T Iizuka, H Kodama, T Abe, Y Seki, M Kodama.   

Abstract

Copper incorporation into ceruloplasmin during ceruloplasmin synthesis was studied by comparing LEC and control rats. Major 132 and 136 kDa ceruloplasmins were found in microsomes and the Golgi apparatus, respectively, isolated from liver homogenates of LEC and control rats. Copper analysis showed that no copper was detected in the ceruloplasmin in the microsomes of either rat. Copper was present in ceruloplasmin in the Golgi apparatus and serum of controls, while it was not detected in ceruloplasmin in the Golgi apparatus and serum of the LEC rat. These results indicate that copper is incorporated into ceruloplasmin in the Golgi apparatus of normal hepatocytes. LEC rats fail to incorporate copper into ceruloplasmin in the Golgi apparatus.

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Year:  1995        PMID： 7726856     DOI： 10.1006/bbrc.1995.1510

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Copper and ceruloplasmin metabolism in the LEC rat, an animal model for Wilson disease.

Authors:  H Kodama; Y Murata; D Mochizuki; T Abe
Journal:  J Inherit Metab Dis       Date:  1998-06       Impact factor: 4.982

2.  Establishment of hepatic and neural differentiation platforms of Wilson's disease specific induced pluripotent stem cells.

Authors:  Fei Yi; Jing Qu; Mo Li; Keiichiro Suzuki; Na Young Kim; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
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3.  Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments.

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Journal:  Biochem J       Date:  1997-09-15       Impact factor: 3.857

Review 4.  Animal models of Wilson disease.

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Journal:  J Neurochem       Date:  2018-06-26       Impact factor: 5.372

5.  Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.

Authors:  Yoshinori Takahashi; Koichiro Kako; Shin-Ichi Kashiwabara; Akio Takehara; Yoshiko Inada; Hidenori Arai; Kazuto Nakada; Hiroko Kodama; Jun-Ichi Hayashi; Tadashi Baba; Eisuke Munekata
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

6.  Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.

Authors:  M J Petris; J F Mercer; J G Culvenor; P Lockhart; P A Gleeson; J Camakaris
Journal:  EMBO J       Date:  1996-11-15       Impact factor: 11.598

Review 7.  Copper transporting P-type ATPases and human disease.

Authors:  Diane W Cox; Steven D P Moore
Journal:  J Bioenerg Biomembr       Date:  2002-10       Impact factor: 2.945

8.  Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis.

Authors:  Ming Song; Zhenyuan Song; Shirish Barve; Jingwen Zhang; Theresa Chen; Marcia Liu; Gavin E Arteel; George J Brewer; Craig J McClain
Journal:  J Pharmacol Exp Ther       Date:  2008-02-25       Impact factor: 4.030

9.  Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?

Authors:  J R Forbes; D W Cox
Journal:  Am J Hum Genet       Date:  1998-12       Impact factor: 11.025
  9 in total

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