Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli.

Literature DB >> 7726536

Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli.

J S Chapman¹, A Bertasso, L M Cummings, N H Georgopapadakou.

Abstract

Four spontaneous, single-step mutants of Escherichia coli K-12 resistant to low levels of the cephalosporin 3'-quinolone ester Ro 23-9424 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. The mutants were cross-resistant to both cephalosporin (cefotaxime) and quinolone (fleroxacin) components. Accordingly, they had altered porins and replicative DNA biosynthesis resistant to fleroxacin. There was no increase in beta-lactamase activity when tested with nitrocephin, and the penicillin-binding protein profiles were normal.

Entities: Chemical Species

Mesh：

Substances：

Year: 1995 PMID： 7726536 PMCID： PMC162583 DOI： 10.1128/AAC.39.2.564

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. In vitro activities of a dual-action antibacterial agent, Ro 23-9424, and comparative agents.

Authors: G Beskid; V Fallat; E R Lipschitz; D H McGarry; R Cleeland; K Chan; D D Keith; J Unowsky
Journal: Antimicrob Agents Chemother Date: 1989-07 Impact factor: 5.191

2. Regulation of outer membrane protein synthesis in Escherichia coli K-12: deletion of ompC affects expression of the OmpF protein.

Authors: C A Schnaitman; G A McDonald
Journal: J Bacteriol Date: 1984-08 Impact factor: 3.490

3. Promoter exchange between ompF and ompC, genes for osmoregulated major outer membrane proteins of Escherichia coli K-12.

Authors: S Matsuyama; K Inokuchi; S Mizushima
Journal: J Bacteriol Date: 1984-06 Impact factor: 3.490

Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli.

1. In vitro activities of a dual-action antibacterial agent, Ro 23-9424, and comparative agents.

2. Regulation of outer membrane protein synthesis in Escherichia coli K-12: deletion of ompC affects expression of the OmpF protein.

3. Promoter exchange between ompF and ompC, genes for osmoregulated major outer membrane proteins of Escherichia coli K-12.

4. Gene envY of Escherichia coli K-12 affects thermoregulation of major porin expression.

5. Mode of action of the dual-action cephalosporin Ro 23-9424.

6. Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12.

7. Porin channels in Escherichia coli: studies with beta-lactams in intact cells.

8. Frequency of in vitro resistance of Pseudomonas aeruginosa to cefepime, ceftazidime, and cefotaxime.

Review 9. Fluoroquinolone antimicrobial agents.

10. Penicillin-binding proteins in bacteria.

Review 1. Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?