Literature DB >> 7726006

Identification of an amino acid substitution involved in the reduction of sensitivity of HIV-1 to an inhibitor of viral proteinase.

O Turriziani1, G Antonelli, H Jacobsen, J Mous, E Riva, M Pistello, F Dianzani.   

Abstract

Clones derived from HIV variants previously characterized as resistant to Ro31-8959, an inhibitor of viral proteinase (PR), were sequenced. Substitution of glycine by valine at position 48 of the PR protein was found. None of the 20 clones derived from wild type HTLV-IIIB contain this mutation. Since such a position is located in a conserved region of PR, it is possible that the substitution can affect the interaction of the enzyme with the inhibitor.

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Year:  1994        PMID： 7726006

Source DB:  PubMed          Journal:  Acta Virol        ISSN： 0001-723X            Impact factor:   1.162


  7 in total

1.  Viral evolution in response to the broad-based retroviral protease inhibitor TL-3.

Authors:  B Bühler; Y C Lin; G Morris; A J Olson; C H Wong; D D Richman; J H Elder; B E Torbett
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

Review 2.  Resistance to human immunodeficiency virus type 1 protease inhibitors.

Authors:  D Boden; M Markowitz
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

3.  Comparison of drug resistance scores for tipranavir in protease inhibitor-naive patients infected with HIV-1 B and non-B subtypes.

Authors:  Martin Stürmer; Christoph Stephan; Peter Gute; Gaby Knecht; Markus Bickel; Hans-Reinhard Brodt; Hans W Doerr; Lutz Gürtler; Pierre Lecocq; Margriet van Houtte
Journal:  Antimicrob Agents Chemother       Date:  2011-08-08       Impact factor: 5.191

4.  In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects.

Authors:  W J Lech; G Wang; Y L Yang; Y Chee; K Dorman; D McCrae; L C Lazzeroni; J W Erickson; J S Sinsheimer; A H Kaplan
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

5.  Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.

Authors:  J H Condra; D J Holder; W A Schleif; O M Blahy; R M Danovich; L J Gabryelski; D J Graham; D Laird; J C Quintero; A Rhodes; H L Robbins; E Roth; M Shivaprakash; T Yang; J A Chodakewitz; P J Deutsch; R Y Leavitt; F E Massari; J W Mellors; K E Squires; R T Steigbigel; H Teppler; E A Emini
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

Review 6.  Saquinavir. A review of its pharmacology and clinical potential in the management of HIV infection.

Authors:  S Noble; D Faulds
Journal:  Drugs       Date:  1996-07       Impact factor: 9.546

Review 7.  Viral protease inhibitors.

Authors:  Jeffrey Anderson; Celia Schiffer; Sook-Kyung Lee; Ronald Swanstrom
Journal:  Handb Exp Pharmacol       Date:  2009
  7 in total

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