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Literature DB >> 7723850

Molecular mechanisms of tissue determination and pattern formation in amphibian embryos.

H Tiedemann¹, H Tiedemann¹, H Grunz, W Knöchel.

Abstract

Factors of the TGF-beta superfamily (activin, vegetalizing factor) and the FGF family determine endoderm and mesoderm. The dorsoventral polarity of the mesoderm depends on additional factors (BMP-4, Wnt-8, noggin). Activin can directly activate gene transcription by signal transduction. Mesoderm is determined by factors prelocalized in the marginal zone. Its differentiation depends also on the animal ectoderm. Neural inducing factors have been partially purified. A masked neuralizing factor in the ectoderm is activated by induction of the ectoderm to the nervous system. Phorbolester can evoke neuralization signaling.

Entities: Gene

Mesh：

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Year: 1995 PMID： 7723850 DOI： 10.1007/bf01177272

Source DB: PubMed Journal: Naturwissenschaften ISSN： 0028-1042

81 in total

1. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.

Authors: W C Smith; R M Harland
Journal: Cell Date: 1992-09-04 Impact factor: 41.582

2. The two-gradient hypothesis in primary induction. The combined effect of two types of inductors mixed in different ratios.

Authors: L SAXEN; S TOIVONEN
Journal: J Embryol Exp Morphol Date: 1961-09

8. Determination of the dorsal-ventral axis in eggs of Xenopus laevis: complete rescue of uv-impaired eggs by oblique orientation before first cleavage.

Authors: S R Scharf; J C Gerhart
Journal: Dev Biol Date: 1980-09 Impact factor: 3.582

Molecular mechanisms of tissue determination and pattern formation in amphibian embryos.

1. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.

2. The two-gradient hypothesis in primary induction. The combined effect of two types of inductors mixed in different ratios.

3. Mesoderm differentiation in early amphibian embryos depends on the animal cap.

4. Inducing activity of subcellular fractions from amphibian embryos.

5. A labile inhibitor blocks immunoglobulin kappa-light-chain-gene transcription in a pre-B leukemic cell line.

6. The mechanism of embryonic induction: isolation of an inhibitor for the vegetalizing factor.

7. The role of stable complexes that repress and activate eucaryotic genes.

8. Determination of the dorsal-ventral axis in eggs of Xenopus laevis: complete rescue of uv-impaired eggs by oblique orientation before first cleavage.

9. Differential induction of regulatory genes during mesoderm formation in Xenopus laevis embryos.

10. Analysis of Xwnt-4 in embryos of Xenopus laevis: a Wnt family member expressed in the brain and floor plate.

Review 1. The Spemann organizer and embryonic head induction.