Age at menarche and nutritional supplementation.

Retrospective data on age at menarche were collected for 832 Guatemalans 15-30 y in age to test whether exposure to a high energy and high protein supplement (Atole: 163 kcals/682 kJ and 11.5 g protein per cup or 180 mL) during childhood led to earlier menarche than did exposure to a low energy, no protein supplement (Fresco: 59 kcals/247 kJ in 180 mL). Mean age at menarche was similar in Atole (13.75 +/- 1.22 y; mean +/- SD) and Fresco (13.74 +/- 1.36 y) groups. The corresponding value for immigrants (n = 144), subjects not exposed to the supplements, was 13.55 +/- 1.20 y. Year of birth as well as socioeconomic status (SES) were associated with age at menarche. Age at menarche declined by 0.69 y over the 15-y period and menarche occurred earlier in higher SES households. Significant positive interactions between supplement type and SES and between supplement type and year of birth were found, but plausible explanations for them could not be advanced.

RCT Entities:   Population Interventions Outcomes