Literature DB >> 7722461

Autoantibodies produced spontaneously by young 1pr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses.

D A Rowley1, E T Becken, R M Stach.   

Abstract

Young MRL/MPJ-lpr (lpr) mice 8-12 wk old challenged with alloantigen had significantly lower specific cytolytic T lymphocyte (CTL) responses than control MRL/MPJ +/+ mice. Serum from lpr mice compared with serum from ++ or normal C3H mice powerfully suppressed CTL responses in mixed lymphocyte cultures (MLC); absorbing lpr serum on protein G, adding antibody against transforming growth factor beta (TGF-beta) to cultures or dissociating immunoglobulin G (IgG) and TGF-beta before additions to cultures prevented suppression. Apparently autoantibody, similar to IgG produced by normal mice in response to immunization, carries TGF-beta which suppresses CTL responses in vivo and in vitro.

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Year:  1995        PMID： 7722461      PMCID： PMC2192013          DOI： 10.1084/jem.181.5.1875

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  20 in total

1.  Isotype progression and clonality of anti-Sm autoantibodies in MRL/Mp-lpr/lpr mice.

Authors:  R A Eisenberg; S Y Craven; P L Cohen
Journal:  J Immunol       Date:  1987-08-01       Impact factor: 5.422

2.  Subclass restriction of anti-Sm antibodies in MRL mice.

Authors:  R A Eisenberg; J B Winfield; P L Cohen
Journal:  J Immunol       Date:  1982-11       Impact factor: 5.422

3.  Monoclonal autoantibodies to subnucleosomes from a MRL/Mp(-)+/+ mouse. Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA.

Authors:  M J Losman; T M Fasy; K E Novick; M Monestier
Journal:  J Immunol       Date:  1992-03-01       Impact factor: 5.422

4.  Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis.

Authors:  R Watanabe-Fukunaga; C I Brannan; N G Copeland; N A Jenkins; S Nagata
Journal:  Nature       Date:  1992-03-26       Impact factor: 49.962

5.  MRL mice produce anti-Su autoantibody, a specificity associated with systemic lupus erythematosus.

Authors:  E L Treadwell; P Cohen; D Williams; K O'Brien; A Volkman; R Eisenberg
Journal:  J Immunol       Date:  1993-01-15       Impact factor: 5.422

6.  Mechanisms of autoantibody production in autoimmune MRL mice.

Authors:  D S Pisetsky; G A McCarty; D V Peters
Journal:  J Exp Med       Date:  1980-11-01       Impact factor: 14.307

7.  Presence of anti-Sm reactivity in autoimmune mouse strains.

Authors:  R A Eisenberg; E M Tan; F J Dixon
Journal:  J Exp Med       Date:  1978-02-01       Impact factor: 14.307

8.  The role of B cells in lpr/lpr-induced autoimmunity.

Authors:  M J Shlomchik; M P Madaio; D Ni; M Trounstein; D Huszar
Journal:  J Exp Med       Date:  1994-10-01       Impact factor: 14.307

9.  Systemic autoimmune disease arises from polyclonal B cell activation.

Authors:  D M Klinman; A D Steinberg
Journal:  J Exp Med       Date:  1987-06-01       Impact factor: 14.307

10.  Reduction of lupus nephritis in MRL/lpr mice by a bacterial superantigen treatment.

Authors:  C Kim; K A Siminovitch; A Ochi
Journal:  J Exp Med       Date:  1991-12-01       Impact factor: 14.307
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  4 in total

1.  Circulating immunoglobulin-bound transforming growth factor beta at a late tumour-bearing stage impairs antigen-specific responses of CD4+ T cells.

Authors:  M Harada; K Tatsugami; M Nomoto; K Nomoto
Journal:  Clin Exp Immunol       Date:  2002-05       Impact factor: 4.330

2.  Reduced interleukin-12, interleukin-18, and interferon-gamma production with prolonged rat hepatic allograft survival after donor-specific blood transfusion.

Authors:  Y Yamaguchi; F Matsumura; J Liang; E Akizuki; T Matsuda; K Okabe; H Ohshiro; K Ishihara; S Yamada; K Mori; M Ogawa
Journal:  Dig Dis Sci       Date:  2000-12       Impact factor: 3.199

3.  Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection.

Authors:  T E Caver; F X O'Sullivan; L I Gold; H D Gresham
Journal:  J Clin Invest       Date:  1996-12-01       Impact factor: 14.808

4.  Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1.

Authors:  L Z Chen; G M Hochwald; C Huang; G Dakin; H Tao; C Cheng; W J Simmons; G Dranoff; G J Thorbecke
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205
  4 in total

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