Literature DB >> 77213

Induced Robertsonian fusions and tandem translocations in mammalian cell cultures.

T C Hsu, S Pathak, B M Basen, G J Stark.   

Abstract

Cultures of a cattle cell line and a Peromyscus eremicus cell line recovering from a pulse-treatment with mitomycin C, actinomycin D, 33258 Hoechst, and nitrosoguanidine exhibited translocations between chromosomes at the centromeric regions (Robertsonian fusions) as well as between centromere and telomere and between telomeres (tandem translocations). The frequency of Robertsonian fusions was found to be dose-dependent and duration-dependent with the mitomycin treatment. Biarmed chromosomes resulting from fusions may be monocentric or dicentric. Analyses of clones isolated from treated cells suggested that fused chromosomes may perpetuate in the cell populations.

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Year:  1978        PMID： 77213     DOI： 10.1159/000130881

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  7 in total

1.  Zoo-fluorescence in situ hybridization analysis of human and Indian muntjac karyotypes (Muntiacus muntjak vaginalis) reveals satellite DNA clusters at the margins of conserved syntenic segments.

Authors:  L Frönicke; H Scherthan
Journal:  Chromosome Res       Date:  1997-06       Impact factor: 5.239

2.  Telomere replication, kinetochore organizers, and satellite DNA evolution.

Authors:  G P Holmquist; B Dancis
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  A somatic origin of homologous Robertsonian translocations and isochromosomes.

Authors:  W P Robinson; F Bernasconi; S Basaran; M Yüksel-Apak; G Neri; F Serville; P Balicek; R Haluza; L M Farah; G Lüleci
Journal:  Am J Hum Genet       Date:  1994-02       Impact factor: 11.025

4.  Anti-kinetochore antibodies: use as probes for inactive centromeres.

Authors:  D E Merry; S Pathak; T C Hsu; B R Brinkley
Journal:  Am J Hum Genet       Date:  1985-03       Impact factor: 11.025

5.  Mosaic 13 trisomy due to de novo 13/13 translocation with subsequent fission. Karyotype: 46,XX, - 13, + t(13;13)(p11;q11)/46,XX,del(13)(p11).

Authors:  J P Fryns; P Casaer; H Van den Berghe
Journal:  Hum Genet       Date:  1979-01-25       Impact factor: 4.132

6.  Robertsonian translocation as a result of telomere shortening during replicative senescence and immortalization of bovine oviduct epithelial cells.

Authors:  Ken Murata; Kei Hanzawa; Fumio Kasai; Masakatsu Takeuchi; Tomoko Echigoya; Shigeru Yasumoto
Journal:  In Vitro Cell Dev Biol Anim       Date:  2007-09-09       Impact factor: 2.416

7.  High-throughput analysis of the satellitome revealed enormous diversity of satellite DNAs in the neo-Y chromosome of the cricket Eneoptera surinamensis.

Authors:  Octavio Manuel Palacios-Gimenez; Guilherme Borges Dias; Leonardo Gomes de Lima; Gustavo Campos E Silva Kuhn; Érica Ramos; Cesar Martins; Diogo Cavalcanti Cabral-de-Mello
Journal:  Sci Rep       Date:  2017-07-25       Impact factor: 4.379
  7 in total

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