| Literature DB >> 7720861 |
S Karino1, T Minegishi, Y Ohyama, M Tano, K Nakamura, K Miyamoto, S Tanaka, Y Ibuki.
Abstract
In a previous experiment, it was shown that midkine (MK) was quite abundant in the follicular fluid; the concentration of MK in bovine follicular fluid was estimated to be 125 micrograms/l. To investigate the regulation of MK production in the ovary, we examined the effect of pregnant mare's serum gonadotropin (PMSG) and PMSG-hCG treatment on the expression of MK in rat ovary. The mRNA of midkine (MK) was increased by PMSG injection and decreased by PMSG and hCG injection; the profile of change of mRNA of MK was similar to that of FSH receptor. Using in situ hybridization, we observed that the MK mRNA localized to granulosa cells. These results suggest that the granulosa cells produce MK under the control of gonadotropin.Entities:
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Year: 1995 PMID： 7720861 DOI： 10.1016/0014-5793(95)00231-w
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124