Literature DB >> 7720854

The endozepine ODN stimulates polyphosphoinositide metabolism in rat astrocytes.

C Patte1, H Vaudry, L Desrues, P Gandolfo, I Strijdveen, M Lamacz, M C Tonon.   

Abstract

Astrocytes synthesize a series of peptides called endozepines which act as endogenous ligands of benzodiazepine receptors. The present study demonstrates that the endozepine ODN causes a dose-dependent increase in inositol trisphosphate and a parallel decrease in phosphatidylinositol bisphosphate in cultured rat astrocytes. Pre-incubation of astrocytes with the phospholipase C inhibitor U 73122 or with pertussis toxin totally blocked polyphosphoinositide metabolism. These data show that, in rat astrocytes, ODN stimulates a phospholipase C coupled to a pertussis toxin-sensitive G protein.

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Year:  1995        PMID： 7720854     DOI： 10.1016/0014-5793(95)00209-r

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  The anorexigenic action of the octadecaneuropeptide (ODN) in goldfish is mediated through the MC4R- and subsequently the CRH receptor-signaling pathways.

Authors:  Kouhei Matsuda; Kenji Kojima; Kohei Wada; Keisuke Maruyama; Jérôme Leprince; Marie-Christine Tonon; Minoru Uchiyama; Hubert Vaudry
Journal:  J Mol Neurosci       Date:  2010-03-21       Impact factor: 3.444

Review 2.  Astrocytes: GABAceptive and GABAergic Cells in the Brain.

Authors:  Jianhui Liu; Xuanran Feng; Yi Wang; Xiaohuan Xia; Jialin C Zheng
Journal:  Front Cell Neurosci       Date:  2022-06-10       Impact factor: 6.147

3.  Antioxidant and Anti-Apoptotic Activity of Octadecaneuropeptide Against 6-OHDA Toxicity in Cultured Rat Astrocytes.

Authors:  Hadhemi Kaddour; Yosra Hamdi; Fatma Amri; Seyma Bahdoudi; Ibtissem Bouannee; Jérôme Leprince; Sami Zekri; Hubert Vaudry; Marie-Christine Tonon; David Vaudry; Mohamed Amri; Sana Mezghani; Olfa Masmoudi-Kouki
Journal:  J Mol Neurosci       Date:  2018-10-20       Impact factor: 3.444

4.  Glial Endozepines Inhibit Feeding-Related Autonomic Functions by Acting at the Brainstem Level.

Authors:  Florent Guillebaud; Clémence Girardet; Anne Abysique; Stéphanie Gaigé; Rym Barbouche; Jérémy Verneuil; André Jean; Jérôme Leprince; Marie-Christine Tonon; Michel Dallaporta; Bruno Lebrun; Jean-Denis Troadec
Journal:  Front Neurosci       Date:  2017-05-30       Impact factor: 4.677

Review 5.  Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in in vitro and in vivo Models of Neurodegenerative Diseases.

Authors:  Olfa Masmoudi-Kouki; Amira Namsi; Yosra Hamdi; Seyma Bahdoudi; Ikram Ghouili; Julien Chuquet; Jérôme Leprince; Benjamin Lefranc; Taoufik Ghrairi; Marie-Christine Tonon; Gérard Lizard; David Vaudry
Journal:  Front Endocrinol (Lausanne)       Date:  2020-11-04       Impact factor: 5.555

6.  The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism.

Authors:  Yosra Hamdi; Hadhemi Kaddour; David Vaudry; Seyma Bahdoudi; Salma Douiri; Jérôme Leprince; Helene Castel; Hubert Vaudry; Marie-Christine Tonon; Mohamed Amri; Olfa Masmoudi-Kouki
Journal:  PLoS One       Date:  2012-08-21       Impact factor: 3.240

7.  The stimulatory effect of the octadecaneuropeptide ODN on astroglial antioxidant enzyme systems is mediated through a GPCR.

Authors:  Yosra Hamdi; Hadhemi Kaddour; David Vaudry; Salma Douiri; Seyma Bahdoudi; Jérôme Leprince; Hélène Castel; Hubert Vaudry; Mohamed Amri; Marie-Christine Tonon; Olfa Masmoudi-Kouki
Journal:  Front Endocrinol (Lausanne)       Date:  2012-11-21       Impact factor: 5.555
  7 in total

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