Literature DB >> 7720770

Serum sex hormone levels after replacing carbamazepine with oxcarbazepine.

J I Isojärvi1, A J Pakarinen, A Rautio, O Pelkonen, V V Myllylä.   

Abstract

The function of the hepatic P450 enzyme system was evaluated by measuring the kinetics of antipyrine and serum sex hormone levels were determined in 12 male patients with epilepsy during carbamazepine medication, and two and six months after changing their medication to oxcarbazepine. Antipyrine t1/2 increased and antipyrine CL decreased after the change reflecting normalisation of the liver P450 enzyme system function. Serum sex hormone binding globulin levels decreased, and serum dehydroepiandrosterone sulphate increased after the change. The results show that the carbamazepine-associated induction of the liver P450 enzyme system and changes in serum sex hormone balance can be avoided by replacing carbamazepine with oxcarbazepine.

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Year:  1995        PMID： 7720770     DOI： 10.1007/bf00196862

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  19 in total

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Journal:  J Clin Endocrinol Metab       Date:  1988-01       Impact factor: 5.958

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Review 4.  Sex hormone-binding globulin: anatomy and physiology of a new regulatory system.

Authors:  W Rosner; D J Hryb; M S Khan; A M Nakhla; N A Romas
Journal:  J Steroid Biochem Mol Biol       Date:  1991       Impact factor: 4.292

5.  Changes in circulating androgens during short term carbamazepine therapy.

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Journal:  Br J Clin Pharmacol       Date:  1984-03       Impact factor: 4.335

6.  Circulating hormones and pituitary responsiveness in young epileptic men receiving long-term antiepileptic medication.

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Journal:  Epilepsia       Date:  1988 Jul-Aug       Impact factor: 5.864

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Journal:  Clin Pharmacol Ther       Date:  1980-11       Impact factor: 6.875

8.  Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy.

Authors:  J I Isojärvi; T J Laatikainen; A J Pakarinen; K T Juntunen; V V Myllylä
Journal:  N Engl J Med       Date:  1993-11-04       Impact factor: 91.245

9.  Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy.

Authors:  J I Isojärvi; M Repo; A J Pakarinen; O Lukkarinen; V V Myllylä
Journal:  Epilepsia       Date:  1995-04       Impact factor: 5.864

10.  A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease.

Authors:  E Barrett-Connor; K T Khaw; S S Yen
Journal:  N Engl J Med       Date:  1986-12-11       Impact factor: 91.245
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  10 in total

Review 1.  New drugs for the treatment of epilepsy: a practical approach.

Authors:  S Beyenburg; J Bauer; M Reuber
Journal:  Postgrad Med J       Date:  2004-10       Impact factor: 2.401

2.  Oxcarbazepine and carbamazepine: expected and unexpected differences and similarities.

Authors:  Bassel W Abou-Khalil
Journal:  Epilepsy Curr       Date:  2007 May-Jun       Impact factor: 7.500

Review 3.  Oxcarbazepine: an update of its efficacy in the management of epilepsy.

Authors:  K Wellington; K L Goa
Journal:  CNS Drugs       Date:  2001       Impact factor: 5.749

Review 4.  Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy.

Authors:  Jouko I T Isojärvi; Erik Taubøll; Andrew G Herzog
Journal:  CNS Drugs       Date:  2005       Impact factor: 5.749

Review 5.  Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management.

Authors:  J Bauer; J I T Isojärvi; A G Herzog; M Reuber; D Polson; E Taubøll; P Genton; H van der Ven; B Roesing; G J Luef; C A Galimberti; J van Parys; D Flügel; A Bergmann; C E Elger
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-08       Impact factor: 10.154

Review 6.  Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations.

Authors:  James W McAuley; Gail D Anderson
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

7.  [How is oxcarbazepine different from carbamazpine?].

Authors:  D Schmidt; C E Elger
Journal:  Nervenarzt       Date:  2004-02       Impact factor: 1.214

8.  Overview of the clinical pharmacokinetics of oxcarbazepine.

Authors:  Gérard Flesch
Journal:  Clin Drug Investig       Date:  2004       Impact factor: 2.859

Review 9.  [Which antiepileptic drug for men with epilepsy? A critical epileptological and andrological review].

Authors:  J Bauer; D Klingmüller
Journal:  Nervenarzt       Date:  2008-12       Impact factor: 1.214

10.  A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy.

Authors:  Yi Guo; Lang Chen; Dongmei Wu; Liang Yu; Hongbin Sun; Qiong Zhu
Journal:  Biomed Res Int       Date:  2021-07-03       Impact factor: 3.411
  10 in total

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