Literature DB >> 7720179

Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1.

R A Casero1, A R Mank, N H Saab, R Wu, W J Dyer, P M Woster.   

Abstract

Three unsymmetrically substituted polyamine analogues demonstrate significant and selective antitumor effects. Each of the analogues N1-ethyl-N11-propargyl-4,8-diazaundecane (PENSpm), N1-ethyl-N11-(cyclobutyl)methyl-4,8-diazaundecane (CBENSpm), and N1-ethyl-N11-(cyclopropyl)methyl-4,8-diazaundecane (CPENSpm) is cytotoxic to a representative non-small-cell lung carcinoma line, NCI H157, while being only growth-inhibitory to a representative small-cell-lung carcinoma line, NCI H82. Cytotoxicity is accompanied by a significant increase in expression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (SSAT) at the levels of activity and steady-state mRNA. These new analogues are significant both for their cell-type-specific activity and as synthetic prototypes for the addition of SSAT-activated functional groups.

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Year:  1995        PMID： 7720179     DOI： 10.1007/BF00685735

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  29 in total

1.  High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.

Authors:  R A Casero; P Celano; S J Ervin; L Wiest; A E Pegg
Journal:  Biochem J       Date:  1990-09-15       Impact factor: 3.857

2.  Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.

Authors:  C W Porter; B Ganis; P R Libby; R J Bergeron
Journal:  Cancer Res       Date:  1991-07-15       Impact factor: 12.701

3.  Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.

Authors:  R J Bernacki; R J Bergeron; C W Porter
Journal:  Cancer Res       Date:  1992-05-01       Impact factor: 12.701

4.  Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models.

Authors:  B K Chang; R J Bergeron; C W Porter; Y Liang
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

5.  Synthetic polyamine analogues as antineoplastics.

Authors:  R J Bergeron; A H Neims; J S McManis; T R Hawthorne; J R Vinson; R Bortell; M J Ingeno
Journal:  J Med Chem       Date:  1988-06       Impact factor: 7.446

6.  Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase.

Authors:  L Xiao; P Celano; A R Mank; A E Pegg; R A Casero
Journal:  Biochem Biophys Res Commun       Date:  1991-08-30       Impact factor: 3.575

7.  Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.

Authors:  R A Casero; A R Mank; L Xiao; J Smith; R J Bergeron; P Celano
Journal:  Cancer Res       Date:  1992-10-01       Impact factor: 12.701

8.  Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues.

Authors:  M Piechaczyk; J M Blanchard; L Marty; C Dani; F Panabieres; S El Sabouty; P Fort; P Jeanteur
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

9.  Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase.

Authors:  R A Casero; P Celano; S J Ervin; N B Applegren; L Wiest; A E Pegg
Journal:  J Biol Chem       Date:  1991-01-15       Impact factor: 5.157

Review 10.  Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

Authors:  A E Pegg
Journal:  Cancer Res       Date:  1988-02-15       Impact factor: 12.701
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  6 in total

1.  The role of polyamine catabolism in polyamine analogue-induced programmed cell death.

Authors:  H C Ha; P M Woster; J D Yager; R A Casero
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

Review 2.  Polyamines and cancer: implications for chemotherapy and chemoprevention.

Authors:  Shannon L Nowotarski; Patrick M Woster; Robert A Casero
Journal:  Expert Rev Mol Med       Date:  2013-02-22       Impact factor: 5.600

3.  Screening for modulators of spermine tolerance identifies Sky1, the SR protein kinase of Saccharomyces cerevisiae, as a regulator of polyamine transport and ion homeostasis.

Authors:  O Erez; C Kahana
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

Review 4.  Targeting polyamine metabolism for cancer therapy and prevention.

Authors:  Tracy R Murray-Stewart; Patrick M Woster; Robert A Casero
Journal:  Biochem J       Date:  2016-10-01       Impact factor: 3.857

5.  Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.

Authors:  Anne Uimari; Tuomo A Keinänen; Anne Karppinen; Patrick Woster; Pekka Uimari; Juhani Jänne; Leena Alhonen
Journal:  Biochem J       Date:  2009-07-29       Impact factor: 3.857

6.  Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite.

Authors:  Alison V Fraser; Patrick M Woster; Heather M Wallace
Journal:  Biochem J       Date:  2002-10-01       Impact factor: 3.857
  6 in total

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