Literature DB >> 7720066

CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila.

J C Yin1, M Del Vecchio, H Zhou, T Tully.   

Abstract

Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.

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Year:  1995        PMID： 7720066     DOI： 10.1016/0092-8674(95)90375-5

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  175 in total

1.  Multiple memory processes following training that a food is inedible in Aplysia.

Authors:  D Botzer; S Markovich; A J Susswein
Journal:  Learn Mem       Date:  1998 Jul-Aug       Impact factor: 2.460

2.  Deficits in memory tasks of mice with CREB mutations depend on gene dosage.

Authors:  P Gass; D P Wolfer; D Balschun; D Rudolph; U Frey; H P Lipp; G Schütz
Journal:  Learn Mem       Date:  1998 Sep-Oct       Impact factor: 2.460

3.  cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: alterations in the memory mutant dunce.

Authors:  D Lee; D K O'Dowd
Journal:  J Neurosci       Date:  2000-03-15       Impact factor: 6.167

Review 4.  The past, the future and the biology of memory storage.

Authors:  E R Kandel; C Pittenger
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-12-29       Impact factor: 6.237

5.  pCREB in the neonate rat olfactory bulb is selectively and transiently increased by odor preference-conditioned training.

Authors:  J H McLean; C W Harley; A Darby-King; Q Yuan
Journal:  Learn Mem       Date:  1999 Nov-Dec       Impact factor: 2.460

6.  Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning.

Authors:  G E Schafe; C M Atkins; M W Swank; E P Bauer; J D Sweatt; J E LeDoux
Journal:  J Neurosci       Date:  2000-11-01       Impact factor: 6.167

7.  Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats.

Authors:  T L Baker; G S Mitchell
Journal:  J Physiol       Date:  2000-11-15       Impact factor: 5.182

8.  Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase.

Authors:  G E Schafe; N V Nadel; G M Sullivan; A Harris; J E LeDoux
Journal:  Learn Mem       Date:  1999 Mar-Apr       Impact factor: 2.460

9.  Inhibition of calcineurin facilitates the induction of memory for sensitization in Aplysia: requirement of mitogen-activated protein kinase.

Authors:  Shiv K Sharma; Martha W Bagnall; Michael A Sutton; Thomas J Carew
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-02       Impact factor: 11.205

10.  Protein kinase A inhibits a consolidated form of memory in Drosophila.

Authors:  Junjiro Horiuchi; Daisuke Yamazaki; Shintaro Naganos; Toshiro Aigaki; Minoru Saitoe
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-15       Impact factor: 11.205
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