Literature DB >> 7719705

Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression.

H Coon1, A A Hicks, M E Bailey, M Hoff, J Holik, R J Harvey, K J Johnson, M G Darlison, F Reimherr, P Wender.   

Abstract

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABAA receptor alpha 1, alpha 2, alpha 4, alpha 5, alpha 6, beta 1, beta 3 and gamma 2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found.

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Year:  1994        PMID： 7719705     DOI： 10.1097/00041444-199400430-00009

Source DB:  PubMed          Journal:  Psychiatr Genet        ISSN： 0955-8829            Impact factor:   2.458


  5 in total

1.  Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder.

Authors:  A Duffy; G Turecki; P Grof; P Cavazzoni; E Grof; R Joober; B Ahrens; A Berghöfer; B Müller-Oerlinghausen; M Dvoráková; E Libigerová; M Vojtĕchovský; P Zvolský; A Nilsson; R W Licht; N A Rasmussen; M Schou; P Vestergaard; A Holzinger; C Schumann; K Thau; C Robertson; G A Rouleau; M Alda
Journal:  J Psychiatry Neurosci       Date:  2000-09       Impact factor: 6.186

2.  Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers.

Authors:  E H Cook; R Y Courchesne; N J Cox; C Lord; D Gonen; S J Guter; A Lincoln; K Nix; R Haas; B L Leventhal; E Courchesne
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

3.  Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence.

Authors:  Darlene A Kertes; Gursharan Kalsi; Carol A Prescott; Po-Hsiu Kuo; Diana G Patterson; Dermot Walsh; Kenneth S Kendler; Brien P Riley
Journal:  Alcohol Clin Exp Res       Date:  2010-12-08       Impact factor: 3.455

Review 4.  Clinical perspectives on the genetics of schizophrenia: a bottom-up orientation.

Authors:  Willem M A Verhoeven; Siegfried Tuinier
Journal:  Neurotox Res       Date:  2008-10       Impact factor: 3.911

5.  Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Authors:  S H Fatemi; T D Folsom; R J Rooney; P D Thuras
Journal:  Transl Psychiatry       Date:  2013-09-10       Impact factor: 6.222
  5 in total

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