Literature DB >> 7719465

Diastereomeric beta-lactam antibiotics. Analytical methods, isomerization and stereoselective pharmacokinetics.

T Itoh1, H Yamada.   

Abstract

Stereospecific HPLC methods for the determination of various diastereomeric beta-lactam antibiotics are reviewed. Stereoselectivity in the absorption, distribution and excretion of several diastereomeric beta-lactams is summarized. The isomerization of beta-lactam isomers and its influence on the pharmacokinetics and pharmacodynamics are discussed.

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Year:  1995        PMID： 7719465     DOI： 10.1016/0021-9673(94)00932-y

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  2 in total

1.  In vivo efficacies of combinations of beta-lactams, beta-lactamase inhibitors, and rifampin against Acinetobacter baumannii in a mouse pneumonia model.

Authors:  M Wolff; M L Joly-Guillou; R Farinotti; C Carbon
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

2.  Stereoselective disposition of sulbenicillin in humans.

Authors:  T Itoh; N Watanabe; M Ishida; Y Tsuda; S Koyano; T Tsunoi; H Shimada; H Yamada
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191
  2 in total

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