Literature DB >> 7719036

The deafness locus (dn) maps to mouse chromosome 19.

B J Keats1, N Nouri, J M Huang, M Money, D B Webster, C I Berlin.   

Abstract

The deafness mouse has profound sensorineural hearing loss with degeneration of hair cells soon after birth. The mode of inheritance is recessive, and there are no associated phenotypic anomalies. Thus, this mouse provides a model for recessive, non-syndromic, prelingual deafness. We have mapped the gene causing deafness in the mouse to Chromosome (Chr) 19 by analysis of 230 intersubspecific backcross progeny. No recombinants were found with the microsatellite marker D19Mit14. The loci for two guanine nucleotide-binding proteins are tightly linked to this marker, and they are being investigated as possible candidate genes. The identification of the defective gene in the mouse will help to explain the mechanism that causes hair cell degeneration and is likely to identify a homologous gene for deafness in humans.

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Year:  1995        PMID： 7719036     DOI： 10.1007/bf00350886

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  10 in total

1.  A genetic map of the mouse suitable for typing intraspecific crosses.

Authors:  W Dietrich; H Katz; S E Lincoln; H S Shin; J Friedman; N C Dracopoli; E S Lander
Journal:  Genetics       Date:  1992-06       Impact factor: 4.562

2.  Derived guinea pig compound VIIIth nerve action potentials to continuous pure tones.

Authors:  C I Berlin; L J Hood; E K Barlow; C R Morehouse; E G Smith
Journal:  Hear Res       Date:  1991-04       Impact factor: 3.208

3.  Degeneration followed by partial regeneration of the organ of Corti in deafness (dn/dn) mice.

Authors:  D B Webster
Journal:  Exp Neurol       Date:  1992-01       Impact factor: 5.330

4.  A genetic map of the mouse with 4,006 simple sequence length polymorphisms.

Authors:  W F Dietrich; J C Miller; R G Steen; M Merchant; D Damron; R Nahf; A Gross; D C Joyce; M Wessel; R D Dredge
Journal:  Nat Genet       Date:  1994-06       Impact factor: 38.330

5.  Estimated number of loci for autosomal recessive severe nerve deafness within the Israeli Jewish population, with implications for genetic counseling.

Authors:  Z Brownstein; Y Friedlander; E Peritz; T Cohen
Journal:  Am J Med Genet       Date:  1991-12-01

6.  Inner ear pathology in the deafness mutant mouse.

Authors:  G R Bock; K P Steel
Journal:  Acta Otolaryngol       Date:  1983 Jul-Aug       Impact factor: 1.494

Review 7.  A genetic linkage map of the mouse: current applications and future prospects.

Authors:  N G Copeland; N A Jenkins; D J Gilbert; J T Eppig; L J Maltais; J C Miller; W F Dietrich; A Weaver; S E Lincoln; R G Steen
Journal:  Science       Date:  1993-10-01       Impact factor: 47.728

8.  Early degeneration of sensory and ganglion cells in the inner ear of mice with uncomplicated genetic deafness (dn): preliminary observations.

Authors:  R Pujol; A Shnerson; M Lenoir; M S Deol
Journal:  Hear Res       Date:  1983-10       Impact factor: 3.208

Review 9.  Evolution of the mammalian G protein alpha subunit multigene family.

Authors:  T M Wilkie; D J Gilbert; A S Olsen; X N Chen; T T Amatruda; J R Korenberg; B J Trask; P de Jong; R R Reed; M I Simon
Journal:  Nat Genet       Date:  1992-05       Impact factor: 38.330

10.  A non-syndrome form of neurosensory, recessive deafness maps to the pericentromeric region of chromosome 13q.

Authors:  P Guilford; S Ben Arab; S Blanchard; J Levilliers; J Weissenbach; A Belkahia; C Petit
Journal:  Nat Genet       Date:  1994-01       Impact factor: 38.330
  10 in total
  7 in total

Review 1.  Distinct functions of TMC channels: a comparative overview.

Authors:  Xiaomin Yue; Yi Sheng; Lijun Kang; Rui Xiao
Journal:  Cell Mol Life Sci       Date:  2019-10-04       Impact factor: 9.261

2.  Recessive mutations of TMC1 associated with moderate to severe hearing loss.

Authors:  Ayesha Imtiaz; Azra Maqsood; Atteeq U Rehman; Robert J Morell; Jeffrey R Holt; Thomas B Friedman; Sadaf Naz
Journal:  Neurogenetics       Date:  2016-02-16       Impact factor: 2.660

3.  Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses.

Authors:  Q Y Zheng; K R Johnson; L C Erway
Journal:  Hear Res       Date:  1999-04       Impact factor: 3.208

4.  Genomic survey of prepulse inhibition in mouse chromosome substitution strains.

Authors:  M P Leussis; M L Frayne; M Saito; E M Berry; K A Aldinger; G N Rockwell; R P Hammer; A E Baskin-Hill; J B Singer; J H Nadeau; P Sklar; T L Petryshen
Journal:  Genes Brain Behav       Date:  2009-07-21       Impact factor: 3.449

Review 5.  TMC function in hair cell transduction.

Authors:  Jeffrey R Holt; Bifeng Pan; Mounir A Koussa; Yukako Asai
Journal:  Hear Res       Date:  2014-01-11       Impact factor: 3.208

6.  Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.

Authors:  Yanmeng Guo; Yuping Wang; Wei Zhang; Shan Meltzer; Damiano Zanini; Yue Yu; Jiefu Li; Tong Cheng; Zhenhao Guo; Qingxiu Wang; Julie S Jacobs; Yashoda Sharma; Daniel F Eberl; Martin C Göpfert; Lily Yeh Jan; Yuh Nung Jan; Zuoren Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-13       Impact factor: 11.205

7.  The protective effect of metformin against the noise-induced hearing loss.

Authors:  Gülin Gökçen Kesici; Fatma Ceyda Akın Öcal; Seren Gülşen Gürgen; Şaban Remzi Erdem; Ersin Öğüş; Hatice Seyra Erbek; Levent Naci Özlüoğlu
Journal:  Eur Arch Otorhinolaryngol       Date:  2018-10-10       Impact factor: 2.503
  7 in total

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