Literature DB >> 7717638

Avoidable delay in the management of carcinoma of the right colon.

J F Stebbing1, A G Nash.   

Abstract

A retrospective study of 89 consecutive patients with carcinoma of the right colon presenting in a district general hospital over a 5-year period is reported. Of the patients, 74% were anaemic at the time of diagnosis and 27% of these had anaemia or a low mean corpuscular volume (MCV) for a significant time (mean 177 days, range 76-496 days) before developing symptoms. All doctors should be more vigilant towards anaemia or low MCV as presymptomatic indicators of possible colonic disease. Appropriate investigation is required in order to detect disease at an earlier stage and therefore influence survival. Significant delay in the diagnosis of symptomatic disease occurs before referral to hospital (mean 61 days vs 36 days, P < 0.05). Treatment delay is similar whether patients are referred to surgeons or physicians. The preoperative duration of symptoms for emergency admissions was significantly shorter than for elective admissions (mean 50 days vs 119 days, P < 0.05). The 30-day mortality was significantly higher for emergency admissions (20.7% vs 3.3%, P < 0.05). Earlier diagnosis of symptomatic disease may not reduce the proportion of emergency admissions (33%) or improve survival. Many tumours are at an advanced pathological stage (39% node positive) by the time symptoms develop.

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Year:  1995        PMID: 7717638      PMCID: PMC2502499     

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN: 0035-8843            Impact factor:   1.891


  16 in total

1.  General practitioners' awareness of colorectal cancer: a 10 year review.

Authors:  A R Dixon; J Thornton-Holmes; N M Cheetham
Journal:  BMJ       Date:  1990-07-21

Review 2.  Microcytic anemia. Differential diagnosis and management of iron deficiency anemia.

Authors:  A C Massey
Journal:  Med Clin North Am       Date:  1992-05       Impact factor: 5.456

3.  Gastrointestinal investigation of iron deficiency anaemia.

Authors:  I J Cook; P Pavli; J W Riley; K J Goulston; O F Dent
Journal:  Br Med J (Clin Res Ed)       Date:  1986-05-24

4.  Evaluation of microcytosis using serum ferritin and red blood cell distribution width.

Authors:  D van Zeben; R Bieger; R K van Wermeskerken; A Castel; J Hermans
Journal:  Eur J Haematol       Date:  1990-02       Impact factor: 2.997

5.  Age and sex distribution of patients with colorectal cancer.

Authors:  P Fleshner; G Slater; A H Aufses
Journal:  Dis Colon Rectum       Date:  1989-02       Impact factor: 4.585

6.  Symptoms of carcinoma of the colon and rectum.

Authors:  N Keddie; A Hargreaves
Journal:  Lancet       Date:  1968-10-05       Impact factor: 79.321

7.  Presentation, duration of symptoms and staging of colorectal carcinoma.

Authors:  S M Kyle; W H Isbister; M L Yeong
Journal:  Aust N Z J Surg       Date:  1991-02

Review 8.  Primary colonoscopy.

Authors:  R J Leicester
Journal:  Baillieres Clin Gastroenterol       Date:  1991-03

9.  Delay in diagnosis and treatment of symptomatic colorectal cancer.

Authors:  H W Holliday; J D Hardcastle
Journal:  Lancet       Date:  1979-02-10       Impact factor: 79.321

Review 10.  The natural history of colorectal cancer. Opportunities for intervention.

Authors:  S J Winawer; A G Zauber; E Stewart; M J O'Brien
Journal:  Cancer       Date:  1991-02-15       Impact factor: 6.860

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  2 in total

1.  Demographic factors associated with knowledge of colorectal cancer symptoms in a UK population-based survey.

Authors:  C Yardley; C Glover; T G Allen-Mersh
Journal:  Ann R Coll Surg Engl       Date:  2000-05       Impact factor: 1.891

2.  Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia.

Authors:  Orouba Almilaji; Sally D Parry; Sharon Docherty; Jonathon Snook
Journal:  Sci Rep       Date:  2021-06-22       Impact factor: 4.379

  2 in total

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