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Literature DB >> 7716547

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.

L Aguilar-Bryan¹, C G Nichols, S W Wechsler, J P Clement, A E Boyd, G González, H Herrera-Sosa, K Nguy, J Bryan, D A Nelson.

Abstract

Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic beta cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (KATP) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release.

Entities: Chemical Disease Gene

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Year: 1995 PMID： 7716547 DOI： 10.1126/science.7716547

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

326 in total

1. Functional and electrophysiological effects of a novel imidazoline-based K(ATP) channel blocker, IMID-4F.

Authors: G A McPherson; K L Bell; J L Favaloro; M Kubo; N B Standen
Journal: Br J Pharmacol Date: 1999-12 Impact factor: 8.739

2. Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.

Authors: F Reimann; S J Tucker; P Proks; F M Ashcroft
Journal: J Physiol Date: 1999-07-15 Impact factor: 5.182

3. ATP interaction with the open state of the K(ATP) channel.

Authors: D Enkvetchakul; G Loussouarn; E Makhina; C G Nichols
Journal: Biophys J Date: 2001-02 Impact factor: 4.033

4. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.

Authors: Y F Lin; Y N Jan; L Y Jan
Journal: EMBO J Date: 2000-03-01 Impact factor: 11.598

5. The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.

Authors: D Enkvetchakul; G Loussouarn; E Makhina; S L Shyng; C G Nichols
Journal: Biophys J Date: 2000-05 Impact factor: 4.033

6. Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.

Authors: S L Shyng; A Barbieri; A Gumusboga; C Cukras; L Pike; J N Davis; P D Stahl; C G Nichols
Journal: Proc Natl Acad Sci U S A Date: 2000-01-18 Impact factor: 11.205

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.

1. Functional and electrophysiological effects of a novel imidazoline-based K(ATP) channel blocker, IMID-4F.

2. Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.

3. ATP interaction with the open state of the K(ATP) channel.

4. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.

5. The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.

6. Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.

7. The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.

8. Zinc-induced changes in ionic currents of clonal rat pancreatic -cells: activation of ATP-sensitive K+ channels.

9. On the mechanism of ADP-induced alteration of sulphonylurea sensitivity in cardiac ATP-sensitive K(+) channels.

10. The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATP.