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Literature DB >> 7716520

Killing of trypanosomes by the human haptoglobin-related protein.

Abstract

African trypanosomes cause disease in humans and animals. Trypanosoma brucei brucei affects cattle but not humans because of its sensitivity to a subclass of human high density lipoproteins (HDLs) called trypanosome lytic factor (TLF). TLF contains two apolipoproteins that are sufficient to cause lysis of T. b. brucei in vitro. These proteins were identified as the human haptoglobin-related protein and paraoxonase-arylesterase. An antibody to haptoglobin inhibited TLF activity. TLF was shown to exhibit peroxidase activity and to be inhibited by catalase. These results suggest that TLF kills trypanosomes by oxidative damage initiated by its peroxidase activity.

Entities: Chemical Gene Species

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Year: 1995 PMID： 7716520 DOI： 10.1126/science.7716520

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

44 in total

1. Reactive oxygen species activate a Ca2+-dependent cell death pathway in the unicellular organism Trypanosoma brucei brucei.

Authors: E L Ridgley; Z H Xiong; L Ruben
Journal: Biochem J Date: 1999-05-15 Impact factor: 3.857

Review 2. Antimicrobial peptide killing of African trypanosomes.

Authors: J M Harrington
Journal: Parasite Immunol Date: 2011-08 Impact factor: 2.280

3. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

Authors: Jill A Inverso; Timothy S Uphoff; Scott C Johnson; Donna M Paulnock; John M Mansfield
Journal: DNA Cell Biol Date: 2010-05 Impact factor: 3.311

4. Putting sleeping sickness to bed.

Authors: Cassandra Willyard
Journal: Nat Med Date: 2011-01 Impact factor: 53.440

5. Immunobiology of African trypanosomes: need of alternative interventions.

Authors: Toya Nath Baral
Journal: J Biomed Biotechnol Date: 2010-02-23

6. Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.

Authors: Matthew K Higgins; Olga Tkachenko; Alan Brown; Jenny Reed; Jayne Raper; Mark Carrington
Journal: Proc Natl Acad Sci U S A Date: 2013-01-14 Impact factor: 11.205

Killing of trypanosomes by the human haptoglobin-related protein.

1. Reactive oxygen species activate a Ca2+-dependent cell death pathway in the unicellular organism Trypanosoma brucei brucei.

Review 2. Antimicrobial peptide killing of African trypanosomes.

3. Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

4. Putting sleeping sickness to bed.

5. Immunobiology of African trypanosomes: need of alternative interventions.

6. Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.

7. In vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei.

8. Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle.

9. Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity.

10. Identification of haptoglobin as a natural inhibitor of trypanocidal activity in human serum.