Literature DB >> 7714718

Chemical incompatibility between procainamide hydrochloride and glucose following intravenous admixture.

A Sianipar1, J E Parkin, V B Sunderland.   

Abstract

The chemical reaction between procainamide hydrochloride and glucose following admixture to glucose infusion has been investigated. Substantial amounts (10-15% after 10 h at room temperature) of the procainamide is lost with the formation of a mixture of the corresponding alpha- and beta-glucosylamines. The chemical identity of the latter compounds was confirmed by 13C and 1H nuclear magnetic resonance spectroscopy.

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Year:  1994        PMID: 7714718     DOI: 10.1111/j.2042-7158.1994.tb03249.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  2 in total

1.  Glycosylation of aromatic amines I: Characterization of reaction products and kinetic scheme.

Authors:  Madhushree Y Gokhale; William R Kearney; Lee E Kirsch
Journal:  AAPS PharmSciTech       Date:  2009-03-21       Impact factor: 3.246

2.  Stability of Procainamide Injection in Clear Glass Vials and Polyvinyl Chloride Bags.

Authors:  Ronald F Donnelly
Journal:  Hosp Pharm       Date:  2017-08-20
  2 in total

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