Literature DB >> 7713173

A new aspect of the antiproliferative action of peripheral-type benzodiazepine receptor ligands.

A Camins1, C Diez-Fernandez, E Pujadas, J Camarasa, E Escubedo.   

Abstract

Ro 5-4864 (4-chlorodiazepam), PK 11195 (1-(2-chlorophenyl)-1,3-dihydro-1-methyl-propyl)isoquinoline carboxamide) and diazepam inhibit, in a concentration-dependent way, the proliferation of V79 Chinese hamster lung cells (IC50 values were: 65.0 +/- 3.73 microM, 57.70 +/- 4.75 microM and 106.80 +/- 8.89 microM, respectively) without being cytotoxic. This antiproliferative effect is mediated by mitosis arrest in the G2 + M stage without affecting DNA synthesis and seems unrelated to a specific interaction of these drugs with the peripheral-type benzodiazepine receptor.

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Year:  1995        PMID： 7713173     DOI： 10.1016/0014-2999(94)00652-n

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

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Authors:  Amani Batarseh; Keith D Barlow; Daniel B Martinez-Arguelles; Vassilios Papadopoulos
Journal:  Biochim Biophys Acta       Date:  2011-09-18

2.  Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells.

Authors:  Sutapa Mukhopadhyay; Bobby Guillory; Shyamali Mukherjee; Salil K Das
Journal:  Mol Cell Biochem       Date:  2010-03-04       Impact factor: 3.396

3.  Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine.

Authors:  W Xia; S Spector; L Hardy; S Zhao; A Saluk; L Alemane; N L Spector
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

4.  Translocator protein blockade reduces prostate tumor growth.

Authors:  Arlee Fafalios; Ardavan Akhavan; Anil V Parwani; Robert R Bies; Kevin J McHugh; Beth R Pflug
Journal:  Clin Cancer Res       Date:  2009-09-29       Impact factor: 12.531

5.  Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species.

Authors:  D A Fennell; M Corbo; A Pallaska; F E Cotter
Journal:  Br J Cancer       Date:  2001-05-18       Impact factor: 7.640

6.  Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.

Authors:  K Maaser; M Höpfner; A Jansen; G Weisinger; M Gavish; A P Kozikowski; A Weizman; P Carayon; E O Riecken; M Zeitz; H Scherübl
Journal:  Br J Cancer       Date:  2001-11-30       Impact factor: 7.640

7.  The Prognostic Value of Peripheral Benzodiazepine Receptor in Patients with Esophageal Squamous Cell Carcinoma.

Authors:  You-Fang Chen; Jing-Dun Xie; Yu-Chuan Jiang; Dong-Tai Chen; Jia-Hao Pan; Yong-Hua Chen; Yun-Fei Yuan; Zhe-Sheng Wen; Wei-An Zeng
Journal:  J Cancer       Date:  2017-09-20       Impact factor: 4.207

8.  Diazepam diminishes temozolomide efficacy in the treatment of U87 glioblastoma cell line.

Authors:  Jovana Drljača; Aleksandra Popović; Dragica Bulajić; Nebojša Stilinović; Sašenka Vidičević Novaković; Slobodan Sekulić; Ivan Milenković; Srđan Ninković; Marko Ljubković; Ivan Čapo
Journal:  CNS Neurosci Ther       Date:  2022-06-15       Impact factor: 7.035
  8 in total

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