Literature DB >> 7712168

Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes.

C Dettbarn1, R Betto, G Salviati, R Sabbadini, P Palade.   

Abstract

Sphingosylphosphorylcholine (SPC) releases Ca2+ from brain microsomes. SPC-induced CA2+ release differs from IP3-induced Ca2+ release in that it is more extensive in the cerebrum than in the cerebellum. SPC has little effect on [3H] IP3 binding but enhances [3H] ryanodine binding, as expected for an activator of ryanodine receptors. SPC-induced Ca2+ release is inhibited by ryanodine receptor blockers but not by selective blockers of IP3 receptors. We conclude that SPC releases Ca2+ from brain microsomes by activating ryanodine receptors rather than IP3 receptors. Activation of an additional SPC-sensitive pathway for releasing Ca2+ is not precluded.

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Year:  1995        PMID： 7712168     DOI： 10.1016/0006-8993(94)01234-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

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Authors:  Erika Kovacs; Le Xu; Daniel A Pasek; Karoly Liliom; Gerhard Meissner
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7.  Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes.

Authors:  R Betto; A Teresi; F Turcato; G Salviati; R A Sabbadini; K Krown; C C Glembotski; L A Kindman; C Dettbarn; Y Pereon; K Yasui; P T Palade
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  8 in total

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