| Literature DB >> 7712126 |
G J Hanson1, M Clare, N L Summers, L W Lim, D J Neidhart, H S Shieh, A M Stevens.
Abstract
SC-51106, a 'minimal-size' diol-based renin inhibitor lacking a P4 residue, has been co-crystallized with human renin and the structure of the complex determined by X-ray crystallography. This study defines the mode of binding of this important class of renin inhibitor, and in conjunction with molecular modeling, has led to the discovery of a new binding site adjacent to S3, which is termed the 'S3aux(iliary)' subsite.Entities:
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Year: 1994 PMID： 7712126 DOI： 10.1016/s0968-0896(00)82040-4
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641