Literature DB >> 7711160

The Na,K-ATPase hypothesis for bipolar illness.

R S el-Mallakh1, R J Wyatt.   

Abstract

A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity can lead to both mania and depression by increasing membrane excitability and decreasing neurotransmitter release, respectively. Supporting evidence is reviewed, and clinical and research implications are discussed.

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Year:  1995        PMID： 7711160     DOI： 10.1016/0006-3223(94)00201-D

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  36 in total

Review 1.  Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function.

Authors:  D Lichtstein; H Rosen
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

2.  Platelet Na+, K+-ATPase activity as a possible peripheral marker for the neurotoxic effects of phenylalanine in phenylketonuria.

Authors:  M Bedin; C H Estrella; D V Duarte; D Ponzi; C S Dutra-Filho; A T Wyse; M Wajner; C M Wannmacher
Journal:  Metab Brain Dis       Date:  2000-06       Impact factor: 3.584

3.  Na+, K+ ATPase activity is reduced in amygdala of rats with chronic stress-induced anxiety-like behavior.

Authors:  Leonardo Crema; Michele Schlabitz; Bárbara Tagliari; Aline Cunha; Fabrício Simão; Rachel Krolow; Letícia Pettenuzzo; Christianne Salbego; Deusa Vendite; Angela T S Wyse; Carla Dalmaz
Journal:  Neurochem Res       Date:  2010-08-18       Impact factor: 3.996

Review 4.  Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets.

Authors:  Alexei Y Bagrov; Joseph I Shapiro; Olga V Fedorova
Journal:  Pharmacol Rev       Date:  2009-03       Impact factor: 25.468

5.  Tissue-specific protective properties of lithium: comparison of rat kidney, erythrocytes and brain.

Authors:  Lenka Roubalová; Miroslava Vošahlíková; Jiřina Slaninová; Jonáš Kaufman; Martin Alda; Petr Svoboda
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2021-01-06       Impact factor: 3.000

6.  Electrogenic properties of the Na⁺/K⁺ ATPase control transitions between normal and pathological brain states.

Authors:  Giri P Krishnan; Gregory Filatov; Andrey Shilnikov; Maxim Bazhenov
Journal:  J Neurophysiol       Date:  2015-01-14       Impact factor: 2.714

7.  Lithium does not alter the choline/creatine ratio in the temporal lobe of human volunteers as measured by proton magnetic resonance spectroscopy.

Authors:  P H Silverstone; C C Hanstock; S Rotzinger
Journal:  J Psychiatry Neurosci       Date:  1999-05       Impact factor: 6.186

8.  Reduction of hippocampal Na+, K+-ATPase activity in rats subjected to an experimental model of depression.

Authors:  Giovana D Gamaro; Emilio L Streck; Cristiane Matté; Martha E Prediger; Angela T S Wyse; Carla Dalmaz
Journal:  Neurochem Res       Date:  2003-09       Impact factor: 3.996

9.  Intracerebroventricular administration of ouabain alters synaptic plasticity and dopamine release in rat medial prefrontal cortex.

Authors:  Li Sui; Xiao-Jin Song; Jie Ren; Li-Hua Ju; Yan Wang
Journal:  J Neural Transm (Vienna)       Date:  2013-01-12       Impact factor: 3.575

10.  An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder.

Authors:  Nirmala Akula; Jens R Wendland; Kwang H Choi; Francis J McMahon
Journal:  Neuropsychopharmacology       Date:  2015-07-27       Impact factor: 7.853
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