Literature DB >> 7709745

Hepatoprotective effects of diethylcarbamazine in acute liver damage induced by carbon tetrachloride in rats.

R Gonzàlez1, O Ancheta, M Màrquez, S Rodriguez.   

Abstract

This research was carried out to determine a potential role of leukotrienes in the acute hepatotoxicity induced by CCl4 in rats. An inhibitor of leukotrienes biosynthesis, diethylcarbamazine (DEC, 25 and 50 mg.kg-1 ip) exerted hepatoprotective effects, decreasing the activity of alanine aminotransferase in serum and the concentration of liver triglycerides. DEC reduced histological damage of liver evidenced by electron microscopy. The hepatoprotective effects of DEC were dose-dependent. The results favor the role of leukotrienes in CCl4 hepatotoxicity.

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Year:  1994        PMID： 7709745

Source DB:  PubMed          Journal:  Zhongguo Yao Li Xue Bao        ISSN： 0253-9756


  4 in total

1.  Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis.

Authors:  Maria Eduarda Rocha de França; Sura Wanessa Santos Rocha; Wilma Helena Oliveira; Laise Aline Santos; Anne Gabrielle Vasconcelos de Oliveira; Karla Patrícia Sousa Barbosa; Ana Karolina Santana Nunes; Gabriel Barros Rodrigues; Deniele Bezerra Lós; Christina Alves Peixoto
Journal:  Inflammopharmacology       Date:  2017-04-13       Impact factor: 4.473

2.  Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.

Authors:  Gary O Rankin; Suk K Hong; Dianne K Anestis; John G Ball; Monica A Valentovic; Vincent A Graffeo
Journal:  Toxicology       Date:  2012-06-15       Impact factor: 4.221

3.  Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice.

Authors:  Sura Wanessa Santos Rocha; Maria Eduarda Rocha de França; Gabriel Barros Rodrigues; Karla Patrícia Sousa Barbosa; Ana Karolina Santana Nunes; André Filipe Pastor; Anne Gabrielle Vasconcelos Oliveira; Wilma Helena Oliveira; Rayana Leal Almeida Luna; Christina Alves Peixoto
Journal:  Mediators Inflamm       Date:  2014-10-13       Impact factor: 4.711

4.  Immunopathological response of leukocytes against microfilariae and adult worms in white rats infected with Setaria cervi.

Authors:  Sharba Kausar; Wajihullah Khan
Journal:  Vet World       Date:  2017-05-30
  4 in total

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