Literature DB >> 7708722

Benzodiazepine receptors mediate regional blood flow changes in the living human brain.

E Matthew1, P Andreason, K Pettigrew, R E Carson, P Herscovitch, R Cohen, C King, C E Johanson, D J Greenblatt, S M Paul.   

Abstract

We studied the effects of a high-affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography. Administration of lorazepam to healthy volunteers caused time- and dose-dependent reductions in regional cerebral blood flow and self-reported alterations in behavioral/mood parameters. Flumazenil administration reversed these changes. These observations indicated that benzodiazepine-induced effects on regional cerebral blood flow and mood/behavior are mediated at some level through GABA-benzodiazepine receptors, although the specific mechanism remains unclear. The approach described here provides a method for quantifying GABA-benzodiazepine-receptor-mediated neurotransmission in the living human brain and may be useful for studying the role of these receptors in a variety of neuropsychiatric disorders.

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Year:  1995        PMID： 7708722      PMCID： PMC42301          DOI： 10.1073/pnas.92.7.2775

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Maps of receptor binding parameters in the human brain--a kinetic analysis of PET measurements.

Authors:  G Blomqvist; S Pauli; L Farde; L Eriksson; A Persson; C Halldin
Journal:  Eur J Nucl Med       Date:  1990

2.  High densities of benzodiazepine receptors in human cortical areas.

Authors:  C Braestrup; R Albrechtsen; R F Squires
Journal:  Nature       Date:  1977-10-20       Impact factor: 49.962

3.  Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam.

Authors:  D J Greenblatt; K Franke; R I Shader
Journal:  J Chromatogr       Date:  1978-09-01

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Authors:  C Braestrup; R F Squires
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

5.  Reproducibility of resting cerebral blood flow measurements with H2(15)O positron emission tomography in humans.

Authors:  E Matthew; P Andreason; R E Carson; P Herscovitch; K Pettigrew; R Cohen; C King; C E Johanson; S M Paul
Journal:  J Cereb Blood Flow Metab       Date:  1993-09       Impact factor: 6.200

Review 6.  Drug interactions at the GABA receptor-ionophore complex.

Authors:  R W Olsen
Journal:  Annu Rev Pharmacol Toxicol       Date:  1982       Impact factor: 13.820

7.  Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system.

Authors:  L Sokoloff
Journal:  Fed Proc       Date:  1981-06

8.  Increases and decreases in local cerebral glucose utilization in response to GABA agonists.

Authors:  J M Palacios; M J Kuhar; S I Rapoport; E D London
Journal:  Eur J Pharmacol       Date:  1981-05-08       Impact factor: 4.432

9.  Regional specific binding of [11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET.

Authors:  S Pappata; Y Samson; C Chavoix; C Prenant; M Mazière; J C Baron
Journal:  J Cereb Blood Flow Metab       Date:  1988-06       Impact factor: 6.200

10.  Cerebral circulatory and metabolic responses to intravenously administered lorazepam.

Authors:  M A Rockoff; K V Naughton; H M Shapiro; M Ingvar; K F Ray; R L Gagnon; L F Marshall
Journal:  Anesthesiology       Date:  1980-09       Impact factor: 7.892
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  9 in total

1.  Positron-emission tomography imaging of long-term shape recognition challenges.

Authors:  A Rosier; L Cornette; P Dupont; G Bormans; J Michiels; L Mortelmans; G A Orban
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

Review 2.  Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection.

Authors:  Andrew M Slupe; Jeffrey R Kirsch
Journal:  J Cereb Blood Flow Metab       Date:  2018-07-16       Impact factor: 6.200

3.  Anterior cingulate GABA levels predict whole-brain cerebral blood flow.

Authors:  Benjamin W Krause; S Andrea Wijtenburg; Henry H Holcomb; Peter Kochunov; Danny J J Wang; L Elliot Hong; Laura M Rowland
Journal:  Neurosci Lett       Date:  2014-01-04       Impact factor: 3.046

4.  Spatial-temporal patterns of electrocorticographic spectral changes during midazolam sedation.

Authors:  Masaaki Nishida; Maria M Zestos; Eishi Asano
Journal:  Clin Neurophysiol       Date:  2015-11-09       Impact factor: 3.708

5.  The effect of latanoprost on ocular blood flow.

Authors:  Alon Harris; Hanna J Garzozi; Lynne McCranor; Ehud Rechtman; Chi-Wah Yung; Brent Siesky
Journal:  Int Ophthalmol       Date:  2008-02-23       Impact factor: 2.031

6.  A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 T.

Authors:  Stephanie C Licata; J Eric Jensen; David M Penetar; Andrew P Prescot; Scott E Lukas; Perry F Renshaw
Journal:  Psychopharmacology (Berl)       Date:  2009-01-06       Impact factor: 4.530

Review 7.  Effect of Anesthetics on Functional Connectivity of Developing Brain.

Authors:  Xu Chen; Xuemei Zheng; Jianghui Cai; Xiao Yang; Yonghong Lin; Mengjun Wu; Xiaofan Deng; Yong G Peng
Journal:  Front Hum Neurosci       Date:  2022-03-11       Impact factor: 3.169

8.  Single and repeated ketamine treatment induces perfusion changes in sensory and limbic networks in major depressive disorder.

Authors:  Ashish K Sahib; Joana R A Loureiro; Megha M Vasavada; Antoni Kubicki; Shantanu H Joshi; Kai Wang; Roger P Woods; Eliza Congdon; Danny J J Wang; Michael L Boucher; Randall Espinoza; Katherine L Narr
Journal:  Eur Neuropsychopharmacol       Date:  2020-02-12       Impact factor: 5.415

9.  Positive Allosteric Modulator of GABA Lowers BOLD Responses in the Cingulate Cortex.

Authors:  Susanna A Walter; Mikael Forsgren; Karin Lundengård; Rozalyn Simon; Maritha Torkildsen Nilsson; Birgitta Söderfeldt; Peter Lundberg; Maria Engström
Journal:  PLoS One       Date:  2016-03-01       Impact factor: 3.240
  9 in total

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