Literature DB >> 7707871

In situ detection of DNA fragmentation after focal cerebral ischemia in mice.

Y Li1, M Chopp, N Jiang, C Zaloga.   

Abstract

Brains from 5 mice subjected to focal ischemia (2 hours)--reperfusion (22 h), revealed a significant increase (P < 0.01) in cells exhibiting DNA fragmentation (100-200 per section)--ipsilateral hemisphere compared to 0-3 per section found in the contralateral hemisphere and normal (n = 5) and sham operated (n = 5) mice. Neurons were the predominant cells (90-95%) exhibiting DNA fragmentation, and were primarily located in the inner boundary zone to the infarct. Apoptosis may contribute to the development of infarct after transient focal cerebral ischemia.

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Year:  1995        PMID： 7707871     DOI： 10.1016/0169-328x(94)00220-9

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  20 in total

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