| Literature DB >> 7706119 |
K Matsumoto1, K Tanaka, S Matsutani, R Sakazaki, H Hinoo, N Uotani, T Tanimoto, Y Kawamura, S Nakamoto, T Yoshida.
Abstract
Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inhibitory activity (IC50 = 0.0033 microM) against rat group II phospholipase A2 was shown by thielocin A1 beta. Against human group II phospholipase A2, thielocin B3 (IC50 = 0.076 microM) was the most potent.Entities:
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Year: 1995 PMID： 7706119 DOI： 10.7164/antibiotics.48.106
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649