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Literature DB >> 7705885

Xanthine oxidase contributes to lung leak in rats subjected to skin burn.

L K Burton¹, S E Velasco, A Patt, L S Terada, J E Repine.

Abstract

We found that rats subjected to thermal skin injury (skin burn) had increased serum xanthine oxidase (XO) activities, increased serum complement activation (decreased serum CH50 levels), increased erythrocyte (RBC) fragility, increased lung neutrophil accumulation, and increased lung leak compared to sham-treated rats. Treatment of rats with allopurinol (an XO inhibitor) not only decreased serum XO activity, but also decreased complement activation, RBC fragility, lung neutrophil accumulation, and lung leak abnormalities in rats subjected to skin burn. We conclude that XO may contribute to acute lung injury and a number of events associated with the development of acute lung leak following skin burn.

Entities: Chemical Disease Species

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Year: 1995 PMID： 7705885 DOI： 10.1007/bf01534378

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

17 in total

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6 in total

Review 1. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol.

Authors: Pál Pacher; Alex Nivorozhkin; Csaba Szabó
Journal: Pharmacol Rev Date: 2006-03 Impact factor: 25.468