Literature DB >> 7705850

Polymorphism of the pentanucleotide repeat d(AAAAT) within intron 1 of the human tumor suppressor gene p53 (17p13.1).

M Hahn1, R Fislage, A Pingoud.   

Abstract

DyeDeoxy terminator cycle sequencing of allele-specific polymerase chain reaction products has shown that there is a highly polymorphic d(AAAAT) pentanucleotide repeat within the first intron of the human p53 gene. This provides a genetic marker for tumor suppressor p53 gene alterations.

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Year:  1995        PMID： 7705850     DOI： 10.1007/bf00208983

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  3 in total

1.  Testing for germ line p53 mutations in cancer families.

Authors:  F P Li; P Correa; J F Fraumeni
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  1991 Nov-Dec       Impact factor: 4.254

2.  Localization of gene for human p53 tumour antigen to band 17p13.

Authors:  M Isobe; B S Emanuel; D Givol; M Oren; C M Croce
Journal:  Nature       Date:  1986 Mar 6-12       Impact factor: 49.962

3.  Polymerase chain reaction detection of a highly polymorphic VNTR segment in intron 1 of the human p53 gene.

Authors:  M Hahn; J Serth; R Fislage; H Wolfes; E Allhoff; V Jonas; A Pingoud
Journal:  Clin Chem       Date:  1993-03       Impact factor: 8.327
  3 in total
  4 in total

1.  11q13 allelic imbalance discriminates pulmonary carcinoids from tumorlets. A microdissection-based genotyping approach useful in clinical practice.

Authors:  S D Finkelstein; T Hasegawa; T Colby; S A Yousem
Journal:  Am J Pathol       Date:  1999-08       Impact factor: 4.307

2.  The RB1 gene mutation in a child with ectopic intracranial retinoblastoma.

Authors:  Z Onadim; A J Woolford; J E Kingston; J L Hungerford
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

3.  Association of intron microsatellite status and exon mutational profiles of TP53 in human colorectal cancer.

Authors:  Xin Liu; Dandan Feng; Xueyun Huo; Xiaoqin Xiao; Zhenwen Chen
Journal:  Exp Ther Med       Date:  2019-10-10       Impact factor: 2.447

4.  An identical, complex TP53 mutation arising independently in two unrelated families with diverse cancer profiles: the complexity of interpreting cancer risk in carriers.

Authors:  E M Pinto; R C Ribeiro; J Li; L Taja-Chayeb; L F Carrasco; M de Lourdes Peña-Torres; S Vidal-Millán; H Maldonado-Mtz; A Dueñas-González; L McGregor; G P Zambetti
Journal:  Oncogenesis       Date:  2012-02-20       Impact factor: 7.485
  4 in total

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