Literature DB >> 7705609

Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis.

M F Cole1, W H Bowen, X J Zhao, R L Cihlar.   

Abstract

The virulence of Candida albicans strain SC5413 and two isogenic derivatives have been investigated in a rat model of oropharyngeal candidiasis. The results demonstrate that both mutant strains are avirulent in this animal model while the parental strain readily initiates infection. Avirulence is not related to altered growth characteristics or the inability of the strains to undergo yeast-to-hyphal morphogenesis. The potential importance of nutritional sufficiency as a virulence factor as well as the possibility of utilizing such strains in the development of an in vitro expression technology system for Candida albicans is discussed.

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Year:  1995        PMID： 7705609     DOI： 10.1111/j.1574-6968.1995.tb07413.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  12 in total

Review 1.  Candida albicans Biofilms and Human Disease.

Authors:  Clarissa J Nobile; Alexander D Johnson
Journal:  Annu Rev Microbiol       Date:  2015       Impact factor: 15.500

2.  Characterization of Candida albicans colony morphological mutants and their hybrids by means of RAPD-PCR, isoenzyme analysis and pathogenicity analysis.

Authors:  A Novák; C Vágvölgyi; L Emody; M Pesti
Journal:  Folia Microbiol (Praha)       Date:  2004       Impact factor: 2.099

3.  Control of filament formation in Candida albicans by polyamine levels.

Authors:  A B Herrero; M C López; S García; A Schmidt; F Spaltmann; J Ruiz-Herrera; A Dominguez
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

4.  Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus.

Authors:  C D'Enfert; M Diaquin; A Delit; N Wuscher; J P Debeaupuis; M Huerre; J P Latge
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

5.  The Candida albicans ATO Gene Family Promotes Neutralization of the Macrophage Phagolysosome.

Authors:  Heather A Danhof; Michael C Lorenz
Journal:  Infect Immun       Date:  2015-09-08       Impact factor: 3.441

6.  Avirulence of Candida albicans FAS2 mutants in a mouse model of systemic candidiasis.

Authors:  X J Zhao; G E McElhaney-Feser; M J Sheridan; S E Broedel; R L Cihlar
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

7.  Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis.

Authors:  J A Calera; X J Zhao; F De Bernardis; M Sheridan; R Calderone
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

8.  Calcineurin is essential for virulence in Candida albicans.

Authors:  Teresa Bader; Barbara Bodendorfer; Klaus Schröppel; Joachim Morschhäuser
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

Review 9.  Animal models of mucosal Candida infection.

Authors:  Julian R Naglik; Paul L Fidel; Frank C Odds
Journal:  FEMS Microbiol Lett       Date:  2008-04-16       Impact factor: 2.742

10.  RT-PCR analysis of Candida albicans ALS gene expression in a hyposalivatory rat model of oral candidiasis and in HIV-positive human patients.

Authors:  Clayton B Green; Sandra Manfra Marretta; Georgina Cheng; Fady F Faddoul; E J Ehrhart; Lois L Hoyer
Journal:  Med Mycol       Date:  2006-03       Impact factor: 4.076
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