Evaluation of the Salivette as sampling device for monitoring beta-adrenoceptor blocking drugs in saliva.

The Salivette was evaluated with a range of racemic beta-adrenoceptor blocking drugs with different lipophilicity. Recovery from the Salivette appeared to be independent of the stereochemical configuration of the drugs but a significant loss of drug due to the Salivette was observed for all tested drugs. The performance of the method, in terms of accuracy and precision, fitted well within the generally accepted criteria for validation, except near the limit of quantification. The Salivette is successfully used for quantitating salivary beta-blocking drugs.