Literature DB >> 770418

Specific in vivo cleavage of D-serine deaminase and properties of tetrameric polypeptide aggregates of the fragments.

M C Heincz, E McFall.   

Abstract

The primary D-serine deaminase (D-serine dehydratase, EC 4.2.1.14) of Escherichia coli K-12 is unstable within the cell. The protein, a single polypeptide chain, is cleaved at a lysine residue by a cellular proteolytic activity. Fragments containing the active site then aggregate into tetramers, which retain substrate affinity and show very low catalytic activity. Such degradations may represent an evolutionary mechanism for the generation of new enzymes.

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Year:  1976        PMID： 770418      PMCID： PMC233267          DOI： 10.1128/jb.126.1.132-139.1976

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  Positive control in the D-serine deaminase system of Escherichia coli K-12.

Authors:  F R Bloom; E McFall; M C Young; A M Carothers
Journal:  J Bacteriol       Date:  1975-03       Impact factor: 3.490

2.  EQUILIBRIUM ULTRACENTRIFUGATION OF DILUTE SOLUTIONS.

Authors:  D A YPHANTIS
Journal:  Biochemistry       Date:  1964-03       Impact factor: 3.162

3.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

4.  SIMPLIFIED "DISC" (POLYACRYLAMIDE GEL) ELECTROPHORESIS.

Authors:  J T CLARKE
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

5.  The spectrophotometric determination of tyrosine and tryptophan in proteins.

Authors:  T W Goodwin; R A Morton
Journal:  Biochem J       Date:  1946       Impact factor: 3.857

6.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

7.  Effects of protease inhibitors on protein breakdown in Escherichia coli.

Authors:  W F Prouty; A L Goldberg
Journal:  J Biol Chem       Date:  1972-05-25       Impact factor: 5.157

8.  D-serine dehydratase from Escherichia coli. II. Analytical studies and subunit structure.

Authors:  W Dowhan; E E Snell
Journal:  J Biol Chem       Date:  1970-09-25       Impact factor: 5.157

9.  Evolution of a second gene for beta-galactosidase in Escherichia coli.

Authors:  J H Campbell; J A Lengyel; J Langridge
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205

10.  Catabolite repression in the D-serine deaminase system of Escherichia coli K-12.

Authors:  E McFall; F R Bloom
Journal:  J Bacteriol       Date:  1971-01       Impact factor: 3.490
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  1 in total

1.  Simultaneous induction of three catabolic enzymes in Escherichia coli.

Authors:  E Pavlasová; E Stejskalová; B Sikyta
Journal:  Folia Microbiol (Praha)       Date:  1980       Impact factor: 2.099
  1 in total

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