Literature DB >> 7704030

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33.

J B Copeman1, F Cucca, C M Hearne, R J Cornall, P W Reed, K S Rønningen, D E Undlien, L Nisticò, R Buzzetti, R Tosi.   

Abstract

The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage disequilibrium at 21 microsatellite marker loci, using 348 affected sibpair families and 107 simplex families. The microsatellite D2S152 was linked to, and associated with, disease in families from three different populations. Our evidence localizes a new diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152. This places it in a region of chromosome 2q that shows conserved synteny with the region of mouse chromosome 1 containing the murine type 1 diabetes gene, Idd5. These results demonstrate the utility of polymorphic microsatellites for linkage disequilibrium mapping of genes for complex diseases.

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Year:  1995        PMID： 7704030     DOI： 10.1038/ng0195-80

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  39 in total

Review 1.  Genetic predisposition to IDDM.

Authors:  S Caillat-Zucman; J F Bach
Journal:  Clin Rev Allergy Immunol       Date:  2000-12       Impact factor: 8.667

2.  Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.

Authors:  N J Cox; B Wapelhorst; V A Morrison; L Johnson; L Pinchuk; R S Spielman; J A Todd; P Concannon
Journal:  Am J Hum Genet       Date:  2001-08-15       Impact factor: 11.025

3.  In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

Authors:  K A Metcalfe; G A Hitman; M J Fennessy; M I McCarthy; J Tuomilehto; E Tuomilehto-Wolf
Journal:  Diabetologia       Date:  1995-10       Impact factor: 10.122

4.  Tests for linkage and association in nuclear families.

Authors:  E R Martin; N L Kaplan; B S Weir
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

5.  Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.

Authors:  B P Tsao; R M Cantor; K C Kalunian; C J Chen; H Badsha; R Singh; D J Wallace; R C Kitridou; S L Chen; N Shen; Y W Song; D A Isenberg; C L Yu; B H Hahn; J I Rotter
Journal:  J Clin Invest       Date:  1997-02-15       Impact factor: 14.808

6.  The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

Authors:  J A Noble; A M Valdes; M Cook; W Klitz; G Thomson; H A Erlich
Journal:  Am J Hum Genet       Date:  1996-11       Impact factor: 11.025

7.  Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.

Authors:  Ying Liu; Su Yang; Alice A Lin; Luca L Cavalli-Sforza; Bing Su
Journal:  J Mol Evol       Date:  2005-10-04       Impact factor: 2.395

Review 8.  Genetics and pulmonary medicine. 3. Genetic susceptibility to tuberculosis in human populations.

Authors:  R Bellamy
Journal:  Thorax       Date:  1998-07       Impact factor: 9.139

9.  Linkage of cytokine genes to rheumatoid arthritis. Evidence of genetic heterogeneity.

Authors:  S John; A Myerscough; A Marlow; A Hajeer; A Silman; W Ollier; J Worthington
Journal:  Ann Rheum Dis       Date:  1998-06       Impact factor: 19.103

10.  Trials of the beta model for complex inheritance.

Authors:  A Collins; C J MacLean; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-20       Impact factor: 11.205
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