Literature DB >> 7701046

The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat.

C Johansson1, D M Jackson, L Svensson.   

Abstract

The effect of various typical (haloperidol) and atypical (clozapine, raclopride, remoxipride) antipsychotics on phencyclidine (PCP)-induced disruption of sensorimotor gating was tested in rats using an acoustic startle paradigm. Clozapine (4-40 mumol/kg), haloperidol (1-5 mumol/kg) and raclopride (1-12 mumol/kg) failed to reverse PCP-induced disruption of prepulse inhibition (PPI) of the acoustic startle response. In contrast, remoxipride (12-60 mumol/kg) caused a dose-dependent block of this effect. PCP-induced disruption of PPI is a widely accepted animal model of a corresponding behavioural deficit observed in schizophrenia although little evidence has been presented that it is in fact sensitive to antipsychotic agents. The present results indicate that remoxipride behaves in a unique way in this model compared to clozapine, haloperidol and raclopride.

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Year:  1994        PMID： 7701046     DOI： 10.1007/bf02247475

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  31 in total

1.  The effects of phencyclidine on the uptake of 3H-catecholamines by rat striatal and hypothalamic synaptosomes.

Authors:  R E Garey; R G Heath
Journal:  Life Sci       Date:  1976-05-15       Impact factor: 5.037

2.  Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input.

Authors:  H S Hoffman; J R Ison
Journal:  Psychol Rev       Date:  1980-03       Impact factor: 8.934

3.  Gating and habituation of the startle reflex in schizophrenic patients.

Authors:  D L Braff; C Grillon; M A Geyer
Journal:  Arch Gen Psychiatry       Date:  1992-03

4.  Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome.

Authors:  C A Tamminga; G K Thaker; R Buchanan; B Kirkpatrick; L D Alphs; T N Chase; W T Carpenter
Journal:  Arch Gen Psychiatry       Date:  1992-07

5.  A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia.

Authors:  R Y Peng; R S Mansbach; D L Braff; M A Geyer
Journal:  Neuropsychopharmacology       Date:  1990-06       Impact factor: 7.853

6.  Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors.

Authors:  N Mohell; M Sällemark; S Rosqvist; A Malmberg; T Högberg; D M Jackson
Journal:  Eur J Pharmacol       Date:  1993-07-06       Impact factor: 4.432

7.  Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.

Authors:  S O Ogren; H Hall; C Köhler; O Magnusson; L O Lindbom; K Angeby; L Florvall
Journal:  Eur J Pharmacol       Date:  1984-07-20       Impact factor: 4.432

8.  Dopaminergic stimulation disrupts sensorimotor gating in the rat.

Authors:  R S Mansbach; M A Geyer; D L Braff
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

9.  Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat.

Authors:  R S Mansbach; M A Geyer
Journal:  Neuropsychopharmacology       Date:  1989-12       Impact factor: 7.853

10.  Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action.

Authors:  A Y Deutch; M C Lee; M J Iadarola
Journal:  Mol Cell Neurosci       Date:  1992-08       Impact factor: 4.314
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  14 in total

1.  Activation of a nitric-oxide-sensitive cAMP pathway with phencyclidine: elevated hippocampal cAMP levels are temporally associated with deficits in prepulse inhibition.

Authors:  Daniel Klamer; Erik Pålsson; Kim Fejgin; Jianhua Zhang; Jörgen A Engel; Lennart Svensson
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

2.  Dissociable effects of the d- and l- enantiomers of govadine on the disruption of prepulse inhibition by MK-801 and apomorphine in male Long-Evans rats.

Authors:  Brittney R Lins; Wendie N Marks; Anthony G Phillips; John G Howland
Journal:  Psychopharmacology (Berl)       Date:  2017-02-08       Impact factor: 4.530

3.  Influence of CGS 21680, a selective adenosine A(2A) agonist, on the phencyclidine-induced sensorimotor gating deficit and motor behaviour in rats.

Authors:  Jadwiga Wardas; Jolanta Konieczny; Małgorzata Pietraszek
Journal:  Psychopharmacology (Berl)       Date:  2003-04-09       Impact factor: 4.530

Review 4.  Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next.

Authors:  Neal R Swerdlow; David L Braff; Mark A Geyer
Journal:  J Psychopharmacol       Date:  2016-08-18       Impact factor: 4.153

5.  Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in rats.

Authors:  B Pouzet; M Paabøl Andersen; S Hogg
Journal:  Psychopharmacology (Berl)       Date:  2004-08-27       Impact factor: 4.530

6.  Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine.

Authors:  V P Bakshi; M A Geyer
Journal:  Psychopharmacology (Berl)       Date:  1995-11       Impact factor: 4.530

7.  Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic alpha7 receptors.

Authors:  Katsuya Suemaru; Kayo Yasuda; Kenta Umeda; Hiroaki Araki; Kazuhiko Shibata; Tominari Choshi; Satoshi Hibino; Yutaka Gomita
Journal:  Br J Pharmacol       Date:  2004-06-14       Impact factor: 8.739

Review 8.  Pre-attentive processing and schizophrenia: animal studies.

Authors:  Bart A Ellenbroek
Journal:  Psychopharmacology (Berl)       Date:  2003-12-04       Impact factor: 4.530

9.  Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms.

Authors:  Daniel Klamer; Erik Pålsson; Aron Revesz; Jörgen A Engel; Lennart Svensson
Journal:  Psychopharmacology (Berl)       Date:  2004-06-02       Impact factor: 4.530

10.  Atypical anti-schizophrenic drugs prevent changes in cortical N-methyl-D-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups.

Authors:  Noelle C Anastasio; Kenneth M Johnson
Journal:  Pharmacol Biochem Behav       Date:  2008-10       Impact factor: 3.533
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