| Literature DB >> 7700351 |
Abstract
Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.Entities:
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Year: 1995 PMID： 7700351 DOI： 10.1038/374425a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962